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Literature summary extracted from

  • Guy, J.E.; Isupov, M.N.; Littlechild, J.A.
    The structure of an alcohol dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix (2003), J. Mol. Biol., 331, 1041-1051.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.1 multiple anomalous dispersion techniques, X-ray diffraction structure determination and analysis at 1.62 A resolution Aeropyrum pernix

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.1 octanoic acid interacts with the catalytic zinc ion, binding structure Aeropyrum pernix

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.1 Zn2+ catalytic zinc ion Aeropyrum pernix

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.1 Aeropyrum pernix
-
-
-
1.1.1.1 Aeropyrum pernix Q9Y9P9
-
-
1.1.1.1 Aeropyrum pernix DSM 11879 Q9Y9P9
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.1 a primary alcohol + NAD+ = an aldehyde + NADH + H+ active site structure Aeropyrum pernix
a

Subunits

EC Number Subunits Comment Organism
1.1.1.1 tetramer the monomer consista of a catalytic and a cofactor-binding domain, the cofactor is bound between 2 domains in a cleft Aeropyrum pernix

Synonyms

EC Number Synonyms Comment Organism
1.1.1.1 ADH
-
 Aeropyrum pernix
1.1.1.1 medium chain alcohol dehydrogenase
-
 Aeropyrum pernix

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.1 NAD+ the monomer consists of a catalytic and a cofactor-binding domain, the cofactor is bound between 2 domains in a cleft Aeropyrum pernix