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Literature summary extracted from

  • Sivaraman, S.; Sullivan, T.J.; Johnson, F.; Novichenok, P.; Cui, G.; Simmerling, C.; Tonge, P.J.
    Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues (2004), J. Med. Chem., 47, 509-518.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 2-(2-hydroxybenzyl)-phenol uncompetitive inhibition Escherichia coli
1.3.1.9 2-(2-hydroxyphenyl)-phenol uncompetitive inhibition Escherichia coli
1.3.1.9 2-phenoxyphenol noncompetitive inhibition Escherichia coli
1.3.1.9 4-(4-hydroxyphenyl)-phenol uncompetitive inhibition Escherichia coli
1.3.1.9 5-chloro-2-(2,4-dichloro-phenoxy)phenol trivial name triclosan, slow, tight-binding inhibitor Escherichia coli
1.3.1.9 5-chloro-2-phenoxyphenol slow binding inhibitor Escherichia coli
1.3.1.9 5-fluoro-2-phenoxyphenol slow binding inhibitor Escherichia coli
1.3.1.9 5-methyl-2-phenoxyphenol slow binding inhibitor Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 trans-2-dodecenoyl-CoA + NADH
-
Escherichia coli dodecanoyl-CoA + NAD+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 FabI
-
Escherichia coli