Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hoffmann, R.; Rot, A.; Niiyama, S.; Billich, A.
    Steroid sulfatase in the human hair follicle concentrates in the dermal papilla (2001), J. Invest. Dermatol., 117, 1342-1348.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.6.2 pharmacology steroid sulfatase inhibitors could be novel drugs to treat androgen-dependent disorders of the hair follicle such as androgenetic alopecia or hirsutism Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.2 estrone-3-O-sulfamate specific inhibitor, concentration-dependent, complete inhibition at 0.1 mM, 100 nM and 10 nM, 89% inhibition at 1 nM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.6.2 0.0017
-
 dehydroepiandrosterone sulfate
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.6.2 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.2 dehydroepiandrosterone sulfate + H2O Homo sapiens androgen metabolism, dehydroepiandrosterone sulfate may play a part in the pathogenesis of androgenic alopecia dehydroepiandrosterone + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.2 hair follicle scalp biopsies, beard and occipital hair follicles ex vivo, predominantly expressed in the dermal papilla Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.6.2 additional information
-
 higher specific activity in the dermal papilla by a factor of 6-8 than in the connective tissue sheaths or root sheaths Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 dehydroepiandrosterone sulfate + H2O
-
 Homo sapiens dehydroepiandrosterone + sulfate
-
 ?
3.1.6.2 dehydroepiandrosterone sulfate + H2O androgen metabolism, dehydroepiandrosterone sulfate may play a part in the pathogenesis of androgenic alopecia Homo sapiens dehydroepiandrosterone + sulfate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.6.2 37
-
 assay at Homo sapiens