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Literature summary extracted from

  • Akyuez, M.; Erat, M.; Ciftci, M.; Guemuestekin, K.; Bakan, N.
    Effects of some antibiotics on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro and in vivo study (2004), J. Enzyme Inhib. Med. Chem., 19, 361-365.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 amikacin in vitro inhibition Homo sapiens
1.1.1.44 ampicillin in vitro inhibition Homo sapiens
1.1.1.44 cefepime in vitro inhibition Homo sapiens
1.1.1.44 cefepime in vitro and in vivo inhibition, noncompetitive Rattus norvegicus
1.1.1.44 ceftazidim in vitro inhibition Homo sapiens
1.1.1.44 chloramphenicol in vitro inhibition Homo sapiens
1.1.1.44 Ciprofloxacin in vitro inhibition Homo sapiens
1.1.1.44 gentamicin sulfate in vitro inhibition Homo sapiens
1.1.1.44 isepamycin in vitro inhibition Homo sapiens
1.1.1.44 levofloxacin in vitro inhibition Homo sapiens
1.1.1.44 additional information no inhibition by cefozin, decefin, streptomycin, combisid, and meronem Homo sapiens
1.1.1.44 netilmicin
-
 Rattus norvegicus
1.1.1.44 netilmicin sulfate in vitro inhibition Homo sapiens
1.1.1.44 netilmicin sulfate in vitro and in vivo inhibition, competitive Rattus norvegicus
1.1.1.44 ofloxacin in vitro inhibition Homo sapiens
1.1.1.44 penicillin G in vitro inhibition Homo sapiens
1.1.1.44 teicoplanin in vitro inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phosphono-D-gluconate + NADP+ Homo sapiens
-
 D-ribulose 5-phosphate + CO2 + NADPH
-
 ?
1.1.1.44 6-phosphono-D-gluconate + NADP+ Rattus norvegicus
-
 D-ribulose 5-phosphate + CO2 + NADPH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Homo sapiens
-
-
-
1.1.1.44 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44 725.4fold from erythrocytes by ammonium sulfate precipitation, 2',5'-ADP-resin affinity chromatography, and gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 erythrocyte
-
 Homo sapiens
-
1.1.1.44 erythrocyte
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.44 1.89
-
 purified enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phosphono-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH
-
 ?
1.1.1.44 6-phosphono-D-gluconate + NADP+
-
 Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.44 6-phosphogluconate dehydrogenase
-
 Homo sapiens
1.1.1.44 6-phosphogluconate dehydrogenase
-
 Rattus norvegicus
1.1.1.44 6PGD
-
 Homo sapiens
1.1.1.44 6PGD
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.44 25
-
 assay at Homo sapiens
1.1.1.44 25
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.44 8
-
 assay at Homo sapiens
1.1.1.44 8
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.44 NADP+
-
 Homo sapiens
1.1.1.44 NADP+
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.44 0.939
-
 netilmicin pH 8.0, 25°C Rattus norvegicus
1.1.1.44 2.579
-
 cefepime pH 8.0, 25°C Rattus norvegicus