EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.184 | 2,3,4-trinitrobenzenesulfonate sodium | acts on a catalytic lysine located at the cofactor binding site, rapid inactivation of the liver enzyme, kinetics, NADP+, 2'-AMP, 2',5'-ADP, and 2'-phospho-5'-ADP-ribose partly protect, but 4-acetylpyridine, 5'-AMP, 5'-ADP, NMN and NAD+ do not | Oryctolagus cuniculus | |
1.1.1.184 | additional information | protective effects of cofactor derivatives against inactivation by phenylglyoxal and 2,3,4-trinitrobenzenesulfonate sodium, overview | Oryctolagus cuniculus | |
1.1.1.184 | Phenylglyoxal | acts on a catalytic arginine located at the cofactor binding site, rapid inactivation of the liver enzyme, kinetics, NADP+, 2'-AMP, 2',5'-ADP, and 2'-phospho-5'-ADP-ribose partly protect, but 4-acetylpyridine, 5'-AMP, 5'-ADP, NMN and NAD+ do not | Oryctolagus cuniculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.184 | 0.52 | - |
loxoprofen | pH 6.5, 30°C | Oryctolagus cuniculus | |
1.1.1.184 | 0.92 | - |
acetohexamide | pH 6.5, 30°C | Oryctolagus cuniculus | |
1.1.1.184 | 1.44 | - |
befunolol | pH 6.5, 30°C | Oryctolagus cuniculus | |
1.1.1.184 | 3 | - |
daunorubicin | pH 6.5, 30°C | Oryctolagus cuniculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.1.184 | cytosol | - |
Oryctolagus cuniculus | 5829 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.184 | Oryctolagus cuniculus | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.1.1.184 | R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+ | ordered bi bi mechanism, in which NADPH binds first and NADP+ leaves last | Oryctolagus cuniculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.184 | kidney | - |
Oryctolagus cuniculus | - |
1.1.1.184 | liver | - |
Oryctolagus cuniculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.184 | 4-acetylpyridine + NADPH | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.184 | acetohexamide + NADPH | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.184 | befunolol + NADPH | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.184 | daunorubicin + NADPH | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.184 | loxoprofen + NADPH | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.184 | additional information | substrate specificity | Oryctolagus cuniculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.184 | carbonyl reductase | - |
Oryctolagus cuniculus |
1.1.1.184 | CR | - |
Oryctolagus cuniculus |
1.1.1.184 | RLCR | - |
Oryctolagus cuniculus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.184 | 30 | - |
assay at | Oryctolagus cuniculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.184 | 6.5 | - |
assay at | Oryctolagus cuniculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.184 | NADPH | catalytically important arginine and lysine residues are located in the enzymes' cofactor binding site and interact with the 2'-phosphate group of the cofactor | Oryctolagus cuniculus |