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Literature summary extracted from

  • Imamura, Y.; Koga, T.; Shimada, H.; Otagiri, M.
    Inactivation of rabbit liver carbonyl reductase by phenylglyoxal and 2,3,4-trinitrobenzenesulfonate sodium (2003), J. Enzyme Inhib. Med. Chem., 18, 35-39.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.184 2,3,4-trinitrobenzenesulfonate sodium acts on a catalytic lysine located at the cofactor binding site, rapid inactivation of the liver enzyme, kinetics, NADP+, 2'-AMP, 2',5'-ADP, and 2'-phospho-5'-ADP-ribose partly protect, but 4-acetylpyridine, 5'-AMP, 5'-ADP, NMN and NAD+ do not Oryctolagus cuniculus
1.1.1.184 additional information protective effects of cofactor derivatives against inactivation by phenylglyoxal and 2,3,4-trinitrobenzenesulfonate sodium, overview Oryctolagus cuniculus
1.1.1.184 Phenylglyoxal acts on a catalytic arginine located at the cofactor binding site, rapid inactivation of the liver enzyme, kinetics, NADP+, 2'-AMP, 2',5'-ADP, and 2'-phospho-5'-ADP-ribose partly protect, but 4-acetylpyridine, 5'-AMP, 5'-ADP, NMN and NAD+ do not Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.184 0.52
-
 loxoprofen pH 6.5, 30°C Oryctolagus cuniculus
1.1.1.184 0.92
-
 acetohexamide pH 6.5, 30°C Oryctolagus cuniculus
1.1.1.184 1.44
-
 befunolol pH 6.5, 30°C Oryctolagus cuniculus
1.1.1.184 3
-
 daunorubicin pH 6.5, 30°C Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.184 cytosol
-
 Oryctolagus cuniculus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.184 Oryctolagus cuniculus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.184 R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+ ordered bi bi mechanism, in which NADPH binds first and NADP+ leaves last Oryctolagus cuniculus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.184 kidney
-
 Oryctolagus cuniculus
-
1.1.1.184 liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.184 4-acetylpyridine + NADPH
-
 Oryctolagus cuniculus ?
-
 ?
1.1.1.184 acetohexamide + NADPH
-
 Oryctolagus cuniculus ?
-
 ?
1.1.1.184 befunolol + NADPH
-
 Oryctolagus cuniculus ?
-
 ?
1.1.1.184 daunorubicin + NADPH
-
 Oryctolagus cuniculus ?
-
 ?
1.1.1.184 loxoprofen + NADPH
-
 Oryctolagus cuniculus ?
-
 ?
1.1.1.184 additional information substrate specificity Oryctolagus cuniculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.184 carbonyl reductase
-
 Oryctolagus cuniculus
1.1.1.184 CR
-
 Oryctolagus cuniculus
1.1.1.184 RLCR
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.184 30
-
 assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.184 6.5
-
 assay at Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.184 NADPH catalytically important arginine and lysine residues are located in the enzymes' cofactor binding site and interact with the 2'-phosphate group of the cofactor Oryctolagus cuniculus