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Literature summary extracted from

  • Obach, R.S.; Huynh, P.; Allen, M.C.; Beedham, C.
    Human liver aldehyde oxidase: inhibition by 239 drugs (2004), J. Clin. Pharmacol., 44, 7-19.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.3.1 amitriptyline 0.00026 mM, 50% inhibition Homo sapiens
1.2.3.1 amlodipine 0.0055 mM, 50% inhibition Homo sapiens
1.2.3.1 amodiaquine 0.00074 mM, 50% inhibition Homo sapiens
1.2.3.1 chlorpromazine 0.00057 mM, 50% inhibition Homo sapiens
1.2.3.1 clomipramine 0.00048 mM, 50% inhibition Homo sapiens
1.2.3.1 clozapine 0.0044 mM, 50% inhibition Homo sapiens
1.2.3.1 cyclobenzaprine 0.0031 mM, 50% inhibition Homo sapiens
1.2.3.1 domperidone 0.0030 mM, 50% inhibition Homo sapiens
1.2.3.1 erythromycin 0.015 mM, 50% inhibition Homo sapiens
1.2.3.1 estradiol 0.00029 mM, 50% inhibition Homo sapiens
1.2.3.1 ethinyl estradiol 0.00057 mM, 50% inhibition Homo sapiens
1.2.3.1 felodipine 0.00030 mM, 50% inhibition Homo sapiens
1.2.3.1 ketoconazole 0.0035 mM, 50% inhibition Homo sapiens
1.2.3.1 loperamide 0.010 mM, 50% inhibition Homo sapiens
1.2.3.1 loratidine 0.00049 mM, 50% inhibition Homo sapiens
1.2.3.1 loxapine 0.0023 mM, 50% inhibition Homo sapiens
1.2.3.1 maprotiline 0.0014 mM, 50% inhibition Homo sapiens
1.2.3.1 menadione 0.00020 mM, 50% inhibition Homo sapiens
1.2.3.1 metoclopramide 0.031 mM, 50% inhibition Homo sapiens
1.2.3.1 norclomipramine 0.00060 mM, 50% inhibition Homo sapiens
1.2.3.1 nortriptyline 0.00085 mM, 50% inhibition Homo sapiens
1.2.3.1 olanzapine 0.0060 mM, 50% inhibition Homo sapiens
1.2.3.1 ondansetron 0.0021 mM, 50% inhibition Homo sapiens
1.2.3.1 perphenazine 0.00003 mM, 50% inhibition Homo sapiens
1.2.3.1 promazine 0.0016 mM, 50% inhibition Homo sapiens
1.2.3.1 Promethazine 0.00051 mM, 50% inhibition Homo sapiens
1.2.3.1 propafenone 0.0025 mM, 50% inhibition Homo sapiens
1.2.3.1 quetiapine 0.0014 mM, 50% inhibition Homo sapiens
1.2.3.1 Quinacrine 0.0033 mM, 50% inhibition Homo sapiens
1.2.3.1 raloxifene 0.000003 mM, 50% inhibition Homo sapiens
1.2.3.1 salmeterol 0.0099 mM, 50% inhibition Homo sapiens
1.2.3.1 tacrine 0.0050 mM, 50% inhibition Homo sapiens
1.2.3.1 tamoxifen 0.0022 mM, 50% inhibition Homo sapiens
1.2.3.1 thioridazine 0.00016 mM, 50% inhibition Homo sapiens
1.2.3.1 Trifluperazine 0.00024 mM, 50% inhibition Homo sapiens
1.2.3.1 verapamil 0.0035 mM, 50% inhibition Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
1.2.3.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.3.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.3.1 phthalazine + O2 + H2O
-
 Homo sapiens 1-phthalazinone + H2O2
-
 ?