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Literature summary extracted from

  • Hakamata, W.; Muroi, M.; Nishio, T.; Oku, T.; Takatsuki, A.
    Recognition properties of processing alpha-glucosidase I and alpha-glucosidase II (2004), J. Carbohydr. Chem., 23, 27-39.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.106 2,6-anhydro-1-benzamide-D-glycero-D-ido-heptitol 18.2% inhibition at 1 mM Rattus norvegicus
3.2.1.106 4-nitrophenyl-2-deoxy-alpha-D-glucopyranoside 56.2% inhibition at 5 mM Rattus norvegicus
3.2.1.106 4-nitrophenyl-3-deoxy-alpha-D-glucopyranoside 71.7% inhibition at 5 mM Rattus norvegicus
3.2.1.106 4-nitrophenyl-4-deoxy-alpha-D-glucopyranoside 18.5% inhibition at 5 mM Rattus norvegicus
3.2.1.106 4-nitrophenyl-5-deoxy-alpha-D-glucopyranoside 22.2% inhibition at 5 mM Rattus norvegicus
3.2.1.106 4-nitrophenyl-6-deoxy-alpha-D-glucopyranoside 32.3% inhibition at 5 mM Rattus norvegicus
3.2.1.207 2,6-anhydro-1-benzamide-D-glycero-D-ido-heptitol
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.207 0.76
-
 p-nitrophenyl-2-deoxy-alpha-D-glucopyranoside pH 6.8, 37°C Rattus norvegicus
3.2.1.207 0.92
-
 p-nitrophenyl-alpha-D-glucopyranoside pH 6.8, 37°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.106 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.207 Glc2Man9GlcNAc2 + H2O Rattus norvegicus processing of asparagine-linked oligosaccharides Man9GlcNAc2 + alpha-D-glucose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.106 Rattus norvegicus
-
-
-
3.2.1.207 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.106 liver
-
 Rattus norvegicus
-
3.2.1.207 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.207 4-nitrophenyl alpha-D-glucopyranoside + H2O
-
 Rattus norvegicus 4-nitrophenol + D-glucose
-
 ?
3.2.1.207 Glc2Man9GlcNAc2 + H2O processing of asparagine-linked oligosaccharides Rattus norvegicus Man9GlcNAc2 + alpha-D-glucose
-
 ?
3.2.1.207 p-nitrophenyl-2-deoxy-alpha-D-glucopyranoside + H2O very effective substrate, other deoxy derivatives are not hydrolyzed Rattus norvegicus p-nitrophenol + 2-deoxy-alpha-D-glucose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.106 alpha-glucosidase I
-
 Rattus norvegicus