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Literature summary extracted from

  • Sekiguchi, Y.; Makita, H.; Yamamura, A.; Matsumoto, K.
    A thermostable histamine oxidase from Arthrobacter crystallopoietes KAIT-B-007 (2004), J. Biosci. Bioeng., 97, 104-110.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.22 1,10-phenanthroline 10 mM, 47% inhibition Arthrobacter crystallopoietes
1.4.3.22 2-mercaptoethanol 10 mM, 26% inhibition Arthrobacter crystallopoietes
1.4.3.22 8-hydroxyquinoline 10 mM, 24% inhibition Arthrobacter crystallopoietes
1.4.3.22 alpha,alpha'-dipyridyl 10 mM, 22% inhibition Arthrobacter crystallopoietes
1.4.3.22 Diethyl dithiocarbamate 10 mM, 76% inhibition Arthrobacter crystallopoietes
1.4.3.22 dithiothreitol 10 mM, 12% inhibition Arthrobacter crystallopoietes
1.4.3.22 EDTA 10 mM, 18% inhibition Arthrobacter crystallopoietes
1.4.3.22 hydrazine 10 mM, 95% inhibition Arthrobacter crystallopoietes
1.4.3.22 Iproniazide 10 mM, 43% inhibition Arthrobacter crystallopoietes
1.4.3.22 isoniazide 10 mM, 76% inhibition Arthrobacter crystallopoietes
1.4.3.22 methylhydrazine 10 mM, complete inhibition Arthrobacter crystallopoietes
1.4.3.22 N,N-diethyldithiocarbamate the inactive enzyme is restored with Cu2+ to 65% of its initial activity Arthrobacter crystallopoietes
1.4.3.22 phenylhydrazine 10 mM, complete inhibition Arthrobacter crystallopoietes

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.22 0.51
-
 histamine pH 7.0, 37°C Arthrobacter crystallopoietes

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.22 copper one atom of copper per mol of enzyme protein Arthrobacter crystallopoietes
1.4.3.22 Cu2+ a part of the apoenzyme is reconstituted in presence of Cu2+ Arthrobacter crystallopoietes
1.4.3.22 MgSO4 10 mM, activation to 114% of control Arthrobacter crystallopoietes

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.3.22 81000
-
 gel filtration, native PAGE Arthrobacter crystallopoietes

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.22 Arthrobacter crystallopoietes
-
 KAIT-B-007
-
1.4.3.22 Arthrobacter crystallopoietes KAIT-B-007
-
 KAIT-B-007
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.22
-
 Arthrobacter crystallopoietes

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.22 14.3
-
-
 Arthrobacter crystallopoietes

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.22 1-phenylethylamine + H2O + O2 44% of the activity with histamine Arthrobacter crystallopoietes 1-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.22 1-phenylethylamine + H2O + O2 44% of the activity with histamine Arthrobacter crystallopoietes KAIT-B-007 1-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.22 agmatine + H2O + O2 4% of the activity with histamine Arthrobacter crystallopoietes ?
-
 ?
1.4.3.22 agmatine + H2O + O2 4% of the activity with histamine Arthrobacter crystallopoietes KAIT-B-007 ?
-
 ?
1.4.3.22 butylamine + H2O + O2 22% of the activity with histamine Arthrobacter crystallopoietes butanal + NH3 + H2O2
-
 ?
1.4.3.22 dopamine + H2O + O2 51% of the activity with histamine Arthrobacter crystallopoietes 2-(3,4-dihydroxyphenyl)ethanal + NH3 + H2O2
-
 ?
1.4.3.22 hexylamine + H2O + O2 41% of the activity with histamine Arthrobacter crystallopoietes hexanal + NH3 + H2O2
-
 ?
1.4.3.22 histamine + H2O + O2
-
 Arthrobacter crystallopoietes (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.22 histamine + H2O + O2
-
 Arthrobacter crystallopoietes KAIT-B-007 (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.22 additional information no activity with putrescine, cadaverine, spermine, and spermidine Arthrobacter crystallopoietes ?
-
 ?
1.4.3.22 additional information no activity with putrescine, cadaverine, spermine, and spermidine Arthrobacter crystallopoietes KAIT-B-007 ?
-
 ?
1.4.3.22 pentylamine + H2O + O2 32% of the activity with histamine Arthrobacter crystallopoietes pentanal + NH3 + H2O2
-
 ?
1.4.3.22 propylamine + H2O + O2 7% of the activity with histamine Arthrobacter crystallopoietes propanal + NH3 + H2O2
-
 ?
1.4.3.22 tryptamine + H2O + O2 15% of the activity with histamine Arthrobacter crystallopoietes 1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
 ?
1.4.3.22 tyramine + H2O + O2 36% of the activity with histamine Arthrobacter crystallopoietes 4-hydroxyphenylethanal + NH3 + H2O2
-
 ?
1.4.3.22 tyramine + H2O + O2 36% of the activity with histamine Arthrobacter crystallopoietes KAIT-B-007 4-hydroxyphenylethanal + NH3 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.22 monomer 1 * 81000, SDS-PAGE Arthrobacter crystallopoietes

Synonyms

EC Number Synonyms Comment Organism
1.4.3.22 histamine oxidase
-
 Arthrobacter crystallopoietes

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.4.3.22 65
-
 10 min, stable Arthrobacter crystallopoietes
1.4.3.22 70
-
 10 min, 93% inactivation Arthrobacter crystallopoietes

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.22 9
-
-
 Arthrobacter crystallopoietes

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.4.3.22 6 9 37°C, 30 min, stable Arthrobacter crystallopoietes