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Literature summary extracted from

  • Davis, K.; Foos, T.; Wu, J.Y.; Schloss, J.V.
    Oxygen-induced seizures and inhibition of human glutamate decarboxylase and porcine cysteine sulfinic acid decarboxylase by oxygen and nitric oxide (2001), J. Biomed. Sci., 8, 359-364.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.15 NO
-
 Homo sapiens
4.1.1.15 O2
-
 Homo sapiens
4.1.1.29 NO fusion protein with beta-galactosidase Sus scrofa
4.1.1.29 O2 fusion protein with beta-galactosidase Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.15 Homo sapiens
-
-
-
4.1.1.29 Sus scrofa
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.1.15 L-glutamate = 4-aminobutanoate + CO2 reaction proceeds via radical mechanism Homo sapiens
a
4.1.1.29 3-sulfino-L-alanine = hypotaurine + CO2 reaction proceeds via radical mechanism Sus scrofa
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.15 L-Glu
-
 Homo sapiens 4-Aminobutanoate + CO2
-
 ?
4.1.1.29 Cysteic acid
-
 Sus scrofa 2-Aminoethane sulfonate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.15 GAD65
-
 Homo sapiens
4.1.1.15 GAD67
-
 Homo sapiens
4.1.1.29 CSADI
-
 Sus scrofa
4.1.1.29 CSADII
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.15 0.29
-
 O2 pH 7.3, 25°C, GAD67, recombinant enzyme expressed in Escherichia coli Homo sapiens
4.1.1.15 0.46
-
 O2 pH 7.3, 25°C, GAD56, recombinant enzyme expressed in Escherichia coli Homo sapiens
4.1.1.15 0.5
-
 NO pH 7.3, 25°C, GAD65, recombinant enzyme expressed in Escherichia coli Homo sapiens
4.1.1.15 0.5
-
 NO pH 7.3, 25°C, GAD67, recombinant enzyme expressed in Escherichia coli Homo sapiens
4.1.1.29 0.2
-
 NO CSADII fusion protein with beta-galactosidase Sus scrofa
4.1.1.29 0.22
-
 O2 CSADII fusion protein with beta-galactosidase Sus scrofa
4.1.1.29 0.3
-
 O2 CSADI fusion protein with beta-galactosidase Sus scrofa
4.1.1.29 0.3
-
 NO CSADI fusion protein with beta-galactosidase Sus scrofa