Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Elmore, B.O.; Bollinger, J.A.; Dooley, D.M.
    Human kidney diamine oxidase: heterologous expression, purification, and characterization (2002), J. Biol. Inorg. Chem., 7, 565-579.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.22 overexpressed as a secreted enzyme under the control of a metallothionein promoter in Drosophila S2 cell culture Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.22 0.0028
-
 histamine pH 7.2, 37°C Homo sapiens
1.4.3.22 0.0034
-
 1-Methylhistamine pH 7.2, 37°C Homo sapiens
1.4.3.22 0.02
-
 putrescine pH 7.2, 37°C Homo sapiens
1.4.3.22 0.03
-
 cadaverine pH 7.2, 37°C Homo sapiens
1.4.3.22 0.11
-
 p-dimethylaminomethylbenzylamine pH 7.2, 37°C Homo sapiens
1.4.3.22 0.13
-
 1,3-diaminopropane pH 7.2, 37°C Homo sapiens
1.4.3.22 0.15
-
 1,6-diaminohexane pH 7.2, 37°C Homo sapiens
1.4.3.22 0.63
-
 ethylenediamine pH 7.2, 37°C Homo sapiens
1.4.3.22 1.1
-
 spermidine pH 7.2, 37°C Homo sapiens
1.4.3.22 2.8
-
 L-Lysine methyl ester pH 7.2, 37°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.22 Ca2+ tightly bound, proposed to occupy a second metal-binding site Homo sapiens
1.4.3.22 copper 1.5 mol per mol of dimer Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.22 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.4.3.22 glycoprotein 20-26% glycosylation per weight Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.22 recombinant enzyme Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.22 colon ascending, descending and transverse Homo sapiens
-
1.4.3.22 duodenum
-
 Homo sapiens
-
1.4.3.22 ileocecum
-
 Homo sapiens
-
1.4.3.22 ileum
-
 Homo sapiens
-
1.4.3.22 jejunum
-
 Homo sapiens
-
1.4.3.22 kidney
-
 Homo sapiens
-
1.4.3.22 liver
-
 Homo sapiens
-
1.4.3.22 placenta
-
 Homo sapiens
-
1.4.3.22 prostate
-
 Homo sapiens
-
1.4.3.22 rectum
-
 Homo sapiens
-
1.4.3.22 stomach
-
 Homo sapiens
-
1.4.3.22 vermiform appendix
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.22 1.1
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.22 1,3-diaminopropane + H2O + O2
-
 Homo sapiens 3-aminopropanal + NH3 + H2O2
-
 ?
1.4.3.22 1,6-diaminohexane + H2O + O2
-
 Homo sapiens 6-aminohexanal + NH3 + H2O2
-
 ?
1.4.3.22 1-methylhistamine + H2O + O2
-
 Homo sapiens ?
-
 ?
1.4.3.22 cadaverine + H2O + O2
-
 Homo sapiens ?
-
 ?
1.4.3.22 ethylenediamine + H2O + O2
-
 Homo sapiens ?
-
 ?
1.4.3.22 histamine + H2O + O2
-
 Homo sapiens (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.22 L-lysine methyl ester + H2O + O2
-
 Homo sapiens ?
-
 ?
1.4.3.22 p-dimethylaminomethylbenzylamine + H2O + O2
-
 Homo sapiens ?
-
 ?
1.4.3.22 putrescine + H2O + O2
-
 Homo sapiens ?
-
 ?
1.4.3.22 spermidine + H2O + O2
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.22 6180
-
 1-Methylhistamine pH 7.2, 37°C Homo sapiens
1.4.3.22 7560
-
 ethylenediamine pH 7.2, 37°C Homo sapiens
1.4.3.22 8340
-
 histamine pH 7.2, 37°C Homo sapiens
1.4.3.22 11220
-
 spermidine pH 7.2, 37°C Homo sapiens
1.4.3.22 17580
-
 1,6-diaminohexane pH 7.2, 37°C Homo sapiens
1.4.3.22 20700
-
 L-Lysine methyl ester pH 7.2, 37°C Homo sapiens
1.4.3.22 27180
-
 cadaverine pH 7.2, 37°C Homo sapiens
1.4.3.22 28500
-
 putrescine pH 7.2, 37°C Homo sapiens
1.4.3.22 29220
-
 1,3-diaminopropane pH 7.2, 37°C Homo sapiens
1.4.3.22 32880
-
 p-dimethylaminomethylbenzylamine pH 7.2, 37°C Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.22 7
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.4.3.22 6.2 8.2 pH 6.2: about 75% of maximal activity, pH 8.2: about 60% of maximal activity Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.22 2,4,5-trihydroxyphenylalaninequinone 1.1 mol per mol of dimer Homo sapiens