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Literature summary extracted from

  • Akerman, S.E.; Müller, S.
    Peroxiredoxin-linked detoxification of hydroperoxides in Toxoplasma gondii (2005), J. Biol. Chem., 280, 564-570.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.11.1.24 TgTrx-Px1 and TgTrx-Px2, expression in Escherichia coli Toxoplasma gondii

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.24 tert-butyl hydroperoxide substrate inhibition Toxoplasma gondii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.11.1.24 0.00004
-
tert-butyl hydroperoxide
-
Toxoplasma gondii
1.11.1.24 0.00038
-
H2O2
-
Toxoplasma gondii
1.11.1.24 0.0042
-
thioredoxin
-
Toxoplasma gondii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.11.1.24 cytosol
-
Toxoplasma gondii 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.11.1.24 24600
-
10 * 24600, TgTrx-Px1, SDS-PAGE Toxoplasma gondii
1.11.1.24 25000
-
TgTrx-Px2 monomer, gel filtration Toxoplasma gondii
1.11.1.24 26500
-
1 * 26500, TgTrx-Px2, SDS-PAGE Toxoplasma gondii
1.11.1.24 52000
-
TgTrx-Px2 dimer, gel filtration Toxoplasma gondii
1.11.1.24 150000
-
TgTrx-Px2 hexamer, gel filtration Toxoplasma gondii
1.11.1.24 250000
-
TgTrx-Px1 decamer, gel filtration Toxoplasma gondii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.24 additional information Toxoplasma gondii peroxidases belonging to the class of 1-Cys and 2-Cys peroxiredoxins play crucial roles in maintaining redox balance. TgTrx-Px1 is an extremely potent antioxidant ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.24 Toxoplasma gondii
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.11.1.24
-
Toxoplasma gondii

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.1.24 tachyzoite
-
Toxoplasma gondii
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.24 H2O2 + reduced thioredoxin ping-pong mechanism Toxoplasma gondii H2O + oxidized thioredoxin
-
?
1.11.1.24 additional information peroxidases belonging to the class of 1-Cys and 2-Cys peroxiredoxins play crucial roles in maintaining redox balance. TgTrx-Px1 is an extremely potent antioxidant Toxoplasma gondii ?
-
?
1.11.1.24 tert-butyl hydroperoxide + reduced thioredoxin
-
Toxoplasma gondii tert-butanol + oxidized thioredoxin + H2O
-
?

Subunits

EC Number Subunits Comment Organism
1.11.1.24 decamer 10 * 24600, TgTrx-Px1, SDS-PAGE Toxoplasma gondii
1.11.1.24 dimer 1 * 26500, TgTrx-Px2, SDS-PAGE Toxoplasma gondii
1.11.1.24 hexamer 1 * 26500, TgTrx-Px2, SDS-PAGE Toxoplasma gondii
1.11.1.24 monomer 1 * 26500, TgTrx-Px2, SDS-PAGE Toxoplasma gondii

Synonyms

EC Number Synonyms Comment Organism
1.11.1.24 1-Cys peroxiredoxin
-
Toxoplasma gondii
1.11.1.24 2-Cys peroxiredoxin
-
Toxoplasma gondii
1.11.1.24 TgTrx-Px1
-
Toxoplasma gondii
1.11.1.24 TgTrx-Px2
-
Toxoplasma gondii

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.11.1.24 0.83
-
H2O2
-
Toxoplasma gondii
1.11.1.24 2.79
-
tert-butyl hydroperoxide
-
Toxoplasma gondii