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Literature summary extracted from

  • Oyedotun, K.S.; Yau, P.F.; Lemire, B.D.
    Identification of the heme Axial ligands in the cytochrome b562 of the Saccharomyces cerevisiae succinate dehydrogenase (2004), J. Biol. Chem., 279, 9432-9439.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.5.1
-
 Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
1.3.5.1 C78A mutation in Sdh4 subunit, 94% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction Saccharomyces cerevisiae
1.3.5.1 C78H mutation in Sdh4 subunit, 53% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction Saccharomyces cerevisiae
1.3.5.1 C85A mutation in Sdh4 subunit, 94% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction Saccharomyces cerevisiae
1.3.5.1 H106A mutation in Sdh3 subunit, 78% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction Saccharomyces cerevisiae
1.3.5.1 H113A mutation in Sdh3 subunit, 61% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction Saccharomyces cerevisiae
1.3.5.1 H30A mutation in Sdh3 subunit, 97% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction Saccharomyces cerevisiae
1.3.5.1 H37A mutation in Sdh4 subunit, 100% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction Saccharomyces cerevisiae
1.3.5.1 H46A mutation in Sdh3 subunit, 45% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction Saccharomyces cerevisiae
1.3.5.1 H46D mutation in Sdh3 subunit, 47% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction Saccharomyces cerevisiae
1.3.5.1 H84A mutation in Sdh3 subunit, 97% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction Saccharomyces cerevisiae
1.3.5.1 H99A mutation in Sdh4 subunit, 75% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.5.1 0.0034
-
 2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone 22°C Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.1 membrane
-
 Saccharomyces cerevisiae 16020
-
1.3.5.1 mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.5.1 succinate + ubiquinone Saccharomyces cerevisiae
-
 fumarate + ubiquinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.1 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.1 succinate + 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
-
 Saccharomyces cerevisiae fumarate + 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinol
-
 ?
1.3.5.1 succinate + ubiquinone
-
 Saccharomyces cerevisiae fumarate + ubiquinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.5.1 SDH
-
 Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3.5.1 60
-
 2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone 22°C Saccharomyces cerevisiae