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Literature summary extracted from
- Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein MRP1 (2004), J. Biol. Chem., 279, 48505-48512.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 7.4.2.1 | expression in Spodoptera frugiperda 21 | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 7.4.2.1 | W653C | decreased ATP-dependent LTC4 transport | Homo sapiens |
| 7.4.2.1 | W653Y | higher transport activity than wild-type enzyme | Homo sapiens |
| 7.4.2.1 | Y1302C | decreased ATP-dependent LTC4 transport | Homo sapiens |
| 7.4.2.1 | Y1302W | no effect of ATP binding and hydrolysis | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 7.4.2.1 | 0.046 | - |
ATP | 30°C, pH 7.5, W653Y | Homo sapiens |  |
| 7.4.2.1 | 0.047 | - |
ATP | 30°C, pH 7.5, Y1302W | Homo sapiens | |
| 7.4.2.1 | 0.065 | - |
ATP | 30°C, pH 7.5, W653Y/Y1302W | Homo sapiens | |
| 7.4.2.1 | 0.069 | - |
ATP | 30°C, pH 7.5, wild-type MRP1 | Homo sapiens | |
| 7.4.2.1 | 0.29 | - |
ATP | 30°C, pH 7.5, W653C/Y1302W | Homo sapiens | |
| 7.4.2.1 | 0.311 | - |
ATP | 30°C, pH 7.5, W653C | Homo sapiens | |
| 7.4.2.1 | 0.34 | - |
ATP | 30°C, pH 7.5, Y1302C | Homo sapiens | |
| 7.4.2.1 | 0.395 | - |
ATP | 30°C, pH 7.5, W653Y/Y1302C | Homo sapiens | |
| 7.4.2.1 | 1.573 | - |
ATP | 30°C, pH 7.5, W653C/Y1302C | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.4.2.1 | ATP + H2O + histidine/out | Homo sapiens | - |
ADP + phosphate + histidine/in | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.4.2.1 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.4.2.1 | ATP + H2O + histidine/out | - |
Homo sapiens | ADP + phosphate + histidine/in | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.4.2.1 | histidine permease | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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