EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.146 | expression in HEK-293 cells | Homo sapiens |
1.1.1.146 | expression in HEK-293 cells | Rattus norvegicus |
1.1.1.146 | expression in HEK-293 cells | Mesocricetus auratus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.146 | 2'-hydroxyflavanone | 0.2 mM, more than 90% inhibition of 7-oxocholesterol reduction in liver homogenates | Mesocricetus auratus | |
1.1.1.146 | 2'-hydroxyflavanone | 0.2 mM, more than 90% inhibition of 7-oxocholesterol reduction in liver homogenates | Rattus norvegicus | |
1.1.1.146 | carbenoxolone | 0.01 mM, more than 90% inhibition of 7-oxocholesterol reduction in liver homogenates | Mesocricetus auratus | |
1.1.1.146 | carbenoxolone | 0.01 mM, more than 90% inhibition of 7-oxocholesterol reduction in liver homogenates | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.146 | 0.0003 | - |
corticosterone | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Homo sapiens | |
1.1.1.146 | 0.00031 | - |
11-Dehydrocorticosterone | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Homo sapiens | |
1.1.1.146 | 0.00031 | - |
11-Dehydrocorticosterone | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Rattus norvegicus | |
1.1.1.146 | 0.00038 | - |
7-oxocholesterol | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Mesocricetus auratus | |
1.1.1.146 | 0.0004 | - |
11-Dehydrocorticosterone | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Mesocricetus auratus | |
1.1.1.146 | 0.00042 | - |
7-oxocholesterol | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Rattus norvegicus | |
1.1.1.146 | 0.00049 | - |
7-oxocholesterol | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Homo sapiens | |
1.1.1.146 | 0.00049 | - |
7alpha-hydroxycholesterol | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Mesocricetus auratus | |
1.1.1.146 | 0.00073 | - |
7beta-hydroxycholesterol | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Mesocricetus auratus | |
1.1.1.146 | 0.00074 | - |
7beta-hydroxycholesterol | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Homo sapiens | |
1.1.1.146 | 0.00075 | - |
7beta-hydroxycholesterol | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Rattus norvegicus | |
1.1.1.146 | 0.0012 | - |
corticosterone | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Rattus norvegicus | |
1.1.1.146 | 0.0032 | - |
corticosterone | 37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1 | Mesocricetus auratus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.146 | 7beta-hydroxycholesterol + NADP+ | Homo sapiens | - |
7-oxocholesterol + NADPH | - |
r | |
1.1.1.146 | 7beta-hydroxycholesterol + NADP+ | Rattus norvegicus | - |
7-oxocholesterol + NADPH | - |
r | |
1.1.1.146 | 7beta-hydroxycholesterol + NADP+ | Mesocricetus auratus | - |
7-oxocholesterol + NADPH | - |
r | |
1.1.1.146 | corticosterone + NADP+ | Homo sapiens | - |
11-dehydrocorticosterone + NADPH | - |
r | |
1.1.1.146 | corticosterone + NADP+ | Rattus norvegicus | - |
11-dehydrocorticosterone + NADPH | - |
r | |
1.1.1.146 | corticosterone + NADP+ | Mesocricetus auratus | - |
11-dehydrocorticosterone + NADPH | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.146 | Homo sapiens | - |
- |
- |
1.1.1.146 | Mesocricetus auratus | Q6R0J2 | - |
- |
1.1.1.146 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.146 | kidney | - |
Rattus norvegicus | - |
1.1.1.146 | liver | - |
Homo sapiens | - |
1.1.1.146 | liver | - |
Rattus norvegicus | - |
1.1.1.146 | liver | - |
Mesocricetus auratus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.146 | 2 7-oxocholesterol + 2 NADPH + 2 H+ | - |
Mesocricetus auratus | 7beta-hydroxycholesterol + 7alpha-hydroxycholesterol + 2 NADP+ | 40% and 60%, respectively, in lysates of HEK-293 cells and intact HEK-293 cells expressing 11beta-HSD1 | r | |
1.1.1.146 | 7alpha-hydroxycholesterol + NADP+ | in lysates of HEK-293 cells expressing 11beta-HSD1, no oxidation in intact HEK293 cells expressing 11beta-HSD1 | Mesocricetus auratus | 7-oxocholesterol + NADPH | - |
r | |
1.1.1.146 | 7beta-hydroxycholesterol + NADP+ | - |
Homo sapiens | 7-oxocholesterol + NADPH | - |
r | |
1.1.1.146 | 7beta-hydroxycholesterol + NADP+ | - |
Rattus norvegicus | 7-oxocholesterol + NADPH | - |
r | |
1.1.1.146 | 7beta-hydroxycholesterol + NADP+ | - |
Mesocricetus auratus | 7-oxocholesterol + NADPH | - |
r | |
1.1.1.146 | 7beta-hydroxycholesterol + NADP+ | in lysates of HEK-293 cells expressing 11beta-HSD1, no oxidation in intact HEK293 cells expressing 11beta-HSD1 | Homo sapiens | 7-oxocholesterol + NADPH | - |
r | |
1.1.1.146 | 7beta-hydroxycholesterol + NADP+ | in lysates of HEK-293 cells expressing 11beta-HSD1, no oxidation in intact HEK293 cells expressing 11beta-HSD1 | Rattus norvegicus | 7-oxocholesterol + NADPH | - |
r | |
1.1.1.146 | 7beta-hydroxycholesterol + NADP+ | in lysates of HEK-293 cells expressing 11beta-HSD1, no oxidation in intact HEK293 cells expressing 11beta-HSD1 | Mesocricetus auratus | 7-oxocholesterol + NADPH | - |
r | |
1.1.1.146 | corticosterone + NADP+ | - |
Homo sapiens | 11-dehydrocorticosterone + NADPH | - |
r | |
1.1.1.146 | corticosterone + NADP+ | - |
Rattus norvegicus | 11-dehydrocorticosterone + NADPH | - |
r | |
1.1.1.146 | corticosterone + NADP+ | - |
Mesocricetus auratus | 11-dehydrocorticosterone + NADPH | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.146 | 11beta-HSD1 | - |
Homo sapiens |
1.1.1.146 | 11beta-HSD1 | - |
Rattus norvegicus |
1.1.1.146 | 11beta-HSD1 | - |
Mesocricetus auratus |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Rattus norvegicus |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Mesocricetus auratus |