EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.3 | homopolynucleotides | significantly stimulate the ATPase activity (15-25fold) with the exception of poly(G) and poly(dG), which are non-stimulatory. dT24 binds over 10 times more strongly than dA24 | Severe acute respiratory syndrome-related coronavirus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
5.6.2.3 | - |
Severe acute respiratory syndrome-related coronavirus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.3 | EDTA | - |
Severe acute respiratory syndrome-related coronavirus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
5.6.2.3 | 0.2 | - |
GTP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 0.2 | - |
dATP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 0.22 | - |
dCTP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 0.33 | - |
ATP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 0.35 | - |
dGTP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 0.47 | - |
CTP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 0.55 | - |
UTP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 0.93 | - |
dUTP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.3 | Mg2+ | activity is dependent on | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | Mn2+ | can substitute for Mg2+, 40% of the efficiency with Mg2+ at 2.5 mM | Severe acute respiratory syndrome-related coronavirus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
5.6.2.3 | 70000 | - |
x * 70000, SDS-PAGE | Severe acute respiratory syndrome-related coronavirus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.6.2.3 | ATP + H2O | Severe acute respiratory syndrome-related coronavirus | - |
ADP + phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.6.2.3 | Severe acute respiratory syndrome-related coronavirus | P0C6X7 | replicase polyprotein 1ab | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
5.6.2.3 | - |
Severe acute respiratory syndrome-related coronavirus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.6.2.3 | ATP + H2O | - |
Severe acute respiratory syndrome-related coronavirus | ADP + phosphate | - |
? | |
5.6.2.3 | ATP + H2O | the enzyme exhibited a preference for ATP, dATP, and dCTP over the other NTP/dNTP substrates | Severe acute respiratory syndrome-related coronavirus | ADP + phosphate | - |
? | |
5.6.2.3 | CTP + H2O | - |
Severe acute respiratory syndrome-related coronavirus | CDP + phosphate | - |
? | |
5.6.2.3 | dATP + H2O | the enzyme exhibited a preference for ATP, dATP, and dCTP over the other NTP/dNTP substrates | Severe acute respiratory syndrome-related coronavirus | dADP + phosphate | - |
? | |
5.6.2.3 | dCTP + H2O | the enzyme exhibited a preference for ATP, dATP, and dCTP over the other NTP/dNTP substrates | Severe acute respiratory syndrome-related coronavirus | dCDP + phosphate | - |
? | |
5.6.2.3 | dGTP + H2O | - |
Severe acute respiratory syndrome-related coronavirus | dGDP + phosphate | - |
? | |
5.6.2.3 | dUTP + H2O | - |
Severe acute respiratory syndrome-related coronavirus | dUDP + phosphate | - |
? | |
5.6.2.3 | GTP + H2O | - |
Severe acute respiratory syndrome-related coronavirus | GDP + phosphate | - |
? | |
5.6.2.3 | UTP + H2O | - |
Severe acute respiratory syndrome-related coronavirus | UDP + phosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
5.6.2.3 | ? | x * 70000, SDS-PAGE | Severe acute respiratory syndrome-related coronavirus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
5.6.2.3 | 25 | - |
assay at | Severe acute respiratory syndrome-related coronavirus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
5.6.2.3 | 5.4 | - |
GTP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 7.5 | - |
dGTP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 10.5 | - |
UTP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 13.9 | - |
CTP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 14.3 | - |
dCTP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 14.8 | - |
dATP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 14.8 | - |
dUTP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus | |
5.6.2.3 | 19.1 | - |
ATP | pH 6.6, 25°C | Severe acute respiratory syndrome-related coronavirus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
5.6.2.3 | 6.6 | - |
assay at | Severe acute respiratory syndrome-related coronavirus |