EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.3.8.6 | E370D | mutant is more sensitive against inactivation by 3-thiaglutaryl-CoA compared to the wild-type enzyme, irreversible inactivation | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.8.6 | 2-pentynoyl-CoA | mechanism-based inactivation, inhibition kinetics | Homo sapiens | |
1.3.8.6 | 3-thiaglutaryl-CoA | non-oxidizable analogue, which competes with 2-pentynoyl-CoA for the binding site | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.8.6 | additional information | - |
additional information | reaction and inhibition kinetics | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.8.6 | Homo sapiens | Q92947 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.8.6 | glutaryl-CoA + 2,6-dichlorophenol indophenol | - |
Homo sapiens | crotonoyl-CoA + CO2 + reduced 2,6-dichlorophenol indophenol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.8.6 | GCD | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.3.8.6 | 25 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.3.8.6 | 7.6 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.8.6 | flavin | - |
Homo sapiens | |
1.3.8.6 | additional information | electron acceptor: 2,6-dichlorophenol indophenol | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.8.6 | 0.0069 | - |
3-thiaglutaryl-CoA | pH 7.6, 25°C | Homo sapiens | |
1.3.8.6 | 0.0228 | - |
3-thiaglutaryl-CoA | pH 7.6, 25°C | Homo sapiens |