Literature summary extracted from
Murphy, D.M.; Ivanenkov, V.V.; Kirley, T.L.
Identification of cysteine residues responsible for oxidative cross-linking and chemical inhibition of human nucleoside-triphosphate diphosphohydrolase 3 (2002), J. Biol. Chem., 277, 6162-6169.
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
3.6.1.5 |
C10S |
112% of wild-type ATPase activity, 105% of wild-type ADPase activity, residue responsible for dimer formation |
Homo sapiens |
3.6.1.5 |
C10S/C501S |
148% of wild-type ATPase activity, 133% of wild-type ADPase activity |
Homo sapiens |
3.6.1.5 |
C10S/C501S/C509S |
79% of wild-type ATPase activity, 77% of wild-type ADPase activity |
Homo sapiens |
3.6.1.5 |
C10S/C509S |
103% of wild-type ATPase activity, 99% of wild-type ADPase activity |
Homo sapiens |
3.6.1.5 |
C501S |
130% of wild-type ATPase activity, 130% of wild-type ADPase activity, site of modification by p-chloromercuriphenylsulfonic acid |
Homo sapiens |
3.6.1.5 |
C501S/C509S |
138% of wild-type ATPase activity, 134% of wild-type ADPase activity |
Homo sapiens |
3.6.1.5 |
C509S |
148% of wild-type ATPase activity, 155% of wild-type ADPase activity |
Homo sapiens |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
3.6.1.5 |
additional information |
not inhibitory: N-ethylmaleimide, iodoacetamide, iodoacetic acid |
Homo sapiens |
|
3.6.1.5 |
p-chloromercuriphenylsulfonic acid |
1 mM, 56% of inhibition |
Homo sapiens |
|
3.6.1.5 |
p-hydroxymercuribenzoate |
1 mM, 35% of inhibition |
Homo sapiens |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.6.1.5 |
Homo sapiens |
- |
- |
- |
Subunits
EC Number |
Subunits |
Comment |
Organism |
---|
3.6.1.5 |
dimer |
crosslinking experiments |
Homo sapiens |