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Literature summary extracted from

  • Cecconi, I.; Scaloni, A.; Rastelli, G.; Moroni, M.; Vilardo, P.G.; Costantino, L.; Cappiello, M.; Garland, D.; Carper, D.; Petrash, J.M.; Del Corso, A.; Mura, U.
    Oxidative modification of aldose reductase induced by copper ion. Definition of the metal-protein interaction mechanism (2002), J. Biol. Chem., 277, 42017-42027.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.21 C298S similar sensitivity against Cu2+ as wild-type Homo sapiens
1.1.1.21 C298S similar sensitivity against Cu2+ as wild-type Rattus norvegicus
1.1.1.21 C303S insensitive to inactivation by CuCl2 Homo sapiens

General Stability

EC Number General Stability Organism
1.1.1.21 enzyme is not stable unless dithiothreitol in micromolar range is present Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 CuCl2 addition of dithiothreitol or 2-mercaptoethanol recovers activity Bos taurus
1.1.1.21 CuCl2 0.007 mM, 20% residual activity, addition of dithiothreitol recovers activity Homo sapiens
1.1.1.21 CuCl2 0.007 mM, 20% residual activity, addition of dithiothreitol recovers activity Rattus norvegicus
1.1.1.21 additional information scarcely inhibitory: sorbinil Bos taurus
1.1.1.21 additional information scarcely inhibitory: sorbinil Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.21 35700
-
x * 35700, electrospray ionisation mass spectrometry data Homo sapiens
1.1.1.21 35960
-
x * 35960, electrospray ionisation mass spectrometry data Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Bos taurus
-
-
-
1.1.1.21 Homo sapiens
-
-
-
1.1.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
Rattus norvegicus
-
1.1.1.21 lens
-
Bos taurus
-
1.1.1.21 placenta
-
Homo sapiens
-

Subunits

EC Number Subunits Comment Organism
1.1.1.21 ? x * 35700, electrospray ionisation mass spectrometry data Homo sapiens
1.1.1.21 ? x * 35960, electrospray ionisation mass spectrometry data Bos taurus