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Literature summary extracted from

  • Failer, B.U.; Braun, N.; Zimmermann, H.
    Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase (2002), J. Biol. Chem., 277, 36978-36986.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.6
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.6 EDTA
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.6 0.216
-
 UDP pH 7 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.6 endoplasmic reticulum associated with Rattus norvegicus 5783
-
3.6.1.6 pre-Golgi intermediate associated with Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.6 Ca2+ dependent on. AT 0.5 mM UDP, maximal activity is obtained at 1 mM Ca2+, higher Ca2+ concentrations reduce catalytic activity Rattus norvegicus
3.6.1.6 additional information insensitive to Mg2+ Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.6 45700
-
 x * 45700, calculation from nucleotide sequence Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.6 additional information Rattus norvegicus the enzyme may support glycosylation reactions related to quality control in the endoplasmic reticulum ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.6 Rattus norvegicus Q8K4Y7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.6 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.6 CDP + H2O hydrolyzes nucleoside 5'-diphosphates in the order: UDP, GDP, IDP, GDP Rattus norvegicus CMP + phosphate
-
 ?
3.6.1.6 GDP + H2O hydrolyzes nucleoside 5'-diphosphates in the order: UDP, GDP, IDP, GDP Rattus norvegicus GMP + phosphate
-
 ?
3.6.1.6 GTP + H2O weak activity Rattus norvegicus GDP + phosphate
-
 ?
3.6.1.6 IDP + H2O hydrolyzes nucleoside 5'-diphosphates in the order: UDP, GDP, IDP, GDP Rattus norvegicus IMP + phosphate
-
 ?
3.6.1.6 additional information the enzyme may support glycosylation reactions related to quality control in the endoplasmic reticulum Rattus norvegicus ?
-
 ?
3.6.1.6 additional information no activity with ADP, nucleoside 5'-triphosphates are hydrolyzed to a minor extend, no hydrolysis of nucleoside 5'-monophosphates Rattus norvegicus ?
-
 ?
3.6.1.6 UDP + H2O hydrolyzes nucleoside 5'-diphosphates in the order: UDP, GDP, IDP, GDP Rattus norvegicus UMP + phosphate
-
 ?
3.6.1.6 UTP + H2O weak activity Rattus norvegicus UDP + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.6 ? x * 45700, calculation from nucleotide sequence Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.6 6.5 7.5
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.6.1.6 6 8 pH 6.0: about 80% of maximal activity, pH 8.0: about 70% of maximal activity Rattus norvegicus