Literature summary extracted from

Ramana, K.V.; Chandra, D.; Srivastava, S.; Bhatnagar, A.; Aggarwal, B.B.; Srivastava, S.K.
Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells (2002), J. Biol. Chem., 277, 32063-32070.

Application

EC Number	Application	Comment	Organism
1.1.1.21	medicine	inhibition of enzyme inhibits vascular smooth muscle cell growth upon injuries via a decrease in activity of transcription factor NF-kappaB	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.21	sorbinil	-	Rattus norvegicus
1.1.1.21	TNF-alpha	-	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.21	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.21	muscle	vascular smooth muscle cell	Rattus norvegicus	-

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Release 2023.1 (January 2023)