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Literature summary extracted from

  • Montplaisir, V.; Lan, N.C.; Guimond, J.; Savineau, C.; Bhat, P.V.; Mader, S.
    Recombinant class I aldehyde dehydrogenases specific for all-trans- or 9-cis-retinal (2002), J. Biol. Chem., 277, 17486-17492.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.36 expression in Escherichia coli Rattus norvegicus
1.2.1.36 functional expression of wild-type and chimeric mutant enzymes in Escherichia coli strain BL21(DE3) Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
1.2.1.36 additional information construction of recombinant chimeric enzymes exchanging parts of the enzyme by sequences of the phenobarbital-induced aldehyde dehydrogenase from rat, and vice versa, the chimeric enzymes show altered substrate specificity towards 9-cis- or all-trans-retinal, overview Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.36 additional information
-
additional information kinetics, recombinant wild-type and chimeric mutant enzymes Rattus norvegicus
1.2.1.36 0.0087
-
9-cis-retinal 25°C Rattus norvegicus
1.2.1.36 0.0087
-
9-cis-retinal recombinant wild-type enzyme, pH 7.2, 25°C Rattus norvegicus
1.2.1.36 0.01
-
all-trans-retinal 25°C Rattus norvegicus
1.2.1.36 0.01
-
all-trans-retinal recombinant wild-type enzyme, pH 7.2, 25°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.36 cytosol
-
Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.36 55000
-
x * 55000, recombinant enzyme, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.36 retinal + NAD+ + H2O Rattus norvegicus
-
retinoate + NADH
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.36 Rattus norvegicus
-
-
-
1.2.1.36 Rattus norvegicus
-
class I enzyme
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.2.1.36 retinal + NAD+ + H2O = retinoate + NADH + H+ catalytic active nucleophil Cys302, not responsible for substrate specificity Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.36 kidney
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.36 9-cis-retinal + NAD+ + H2O
-
Rattus norvegicus 9-cis-retinoate + NADH
-
?
1.2.1.36 9-cis-retinal + NAD+ + H2O poortly active with Rattus norvegicus 9-cis-retinoate + NADH
-
?
1.2.1.36 all-trans-retinal + NAD+ + H2O
-
Rattus norvegicus all-trans-retinoate + NADH
-
?
1.2.1.36 propanal + NAD+ + H2O
-
Rattus norvegicus propionate + NADH
-
?
1.2.1.36 retinal + NAD+ + H2O
-
Rattus norvegicus retinoate + NADH
-
?

Subunits

EC Number Subunits Comment Organism
1.2.1.36 ? x * 55000, recombinant enzyme, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.2.1.36 PB-RALDH
-
Rattus norvegicus
1.2.1.36 phenobarbital-induced aldehyde dehydrogenase
-
Rattus norvegicus
1.2.1.36 RALDH
-
Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.36 25
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.36 7.2
-
about, assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.36 NAD+
-
Rattus norvegicus