EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.23 | cardiolipin | activates the ceramidase activity by 2.5fold at 8-10 mol%, inhibits the ceramide synthesis activity, mechanism | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.23 | 2-mercaptoethanol | inhibits both ceramidase and ceramide synthesis activity | Rattus norvegicus | |
3.5.1.23 | C16-ceramide | ceramide synthesis activity, 10 mol%, 50% inhibition | Rattus norvegicus | |
3.5.1.23 | cardiolipin | inhibits the ceramide synthesis activity: total inhibition at 2.5-5 mol%, activates the ceramidase activity, mechanism | Rattus norvegicus | |
3.5.1.23 | CuCl2 | ceramide synthesis activity, 1 mM, total inhibition | Rattus norvegicus | |
3.5.1.23 | dithiothreitol | inhibits both ceramidase and ceramide synthesis activity | Rattus norvegicus | |
3.5.1.23 | L-erythro-sphingosine | competitive inhibitor of ceramide synthesis activity | Rattus norvegicus | |
3.5.1.23 | lysophosphatidylcholine | ceramide synthesis activity, 10 mol%, moderate inhibition | Rattus norvegicus | |
3.5.1.23 | additional information | the ceramide synthesis activity is not inhibited in vitro and in cells by fuminosin B1, not inhibited by EDTA or ATP, both up to 10 mM | Rattus norvegicus | |
3.5.1.23 | myristaldehyde | competitively inhibits the ceramide synthesis activity, 2.5-3 mol%, about 50% inhibition | Rattus norvegicus | |
3.5.1.23 | palmitaldehyde | ceramide synthesis activity, 2.5-3 mol%, about 50% inhibition | Rattus norvegicus | |
3.5.1.23 | phosphatidic acid | ceramide synthesis activity, 2.5-5 mol%, total inhibition | Rattus norvegicus | |
3.5.1.23 | phosphatidylcholine | ceramide synthesis activity, 10 mol%, moderate inhibition | Rattus norvegicus | |
3.5.1.23 | phosphatidylglycerol | ceramide synthesis activity, 10 mol%, moderate inhibition | Rattus norvegicus | |
3.5.1.23 | phosphatidylserine | ceramide synthesis activity, 10 mol%, moderate inhibition | Rattus norvegicus | |
3.5.1.23 | sphingomyelin | ceramide synthesis activity, 5 mol%, 50% inhibition | Rattus norvegicus | |
3.5.1.23 | ZnCl2 | ceramide synthesis activity, 1 mM, total inhibition | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.1.23 | additional information | - |
additional information | kinetic data for the ceramide synthesis reaction, random sequential kinetic mechanism | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.5.1.23 | membrane | membrane-bound, brain | Rattus norvegicus | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.23 | additional information | the ceramide synthesis activity is totally independent of stimulating cations | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.23 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.1.23 | - |
Rattus norvegicus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.5.1.23 | a ceramide + H2O = a carboxylate + sphingosine | kinetic mechanism | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.1.23 | brain | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.23 | D-erythro-dihydrosphingosine + fatty acid | very low ceramide synthesis activity | Rattus norvegicus | ? | - |
? | |
3.5.1.23 | D-erythro-sphingosine + fatty acid | highest ceramide synthesis activity with D-erythro-sphingosine | Rattus norvegicus | ? | - |
? | |
3.5.1.23 | D-threo-sphingosine + fatty acid | low ceramide synthesis activity | Rattus norvegicus | ? | - |
? | |
3.5.1.23 | L-erythro-sphingosine + fatty acid | low ceramide synthesis activity | Rattus norvegicus | ? | - |
? | |
3.5.1.23 | L-threo-sphingosine + fatty acid | low ceramide synthesis activity | Rattus norvegicus | ? | - |
? | |
3.5.1.23 | additional information | no substrate in the ceramide synthesis reaction: palmitoyl-CoA | Rattus norvegicus | ? | - |
? | |
3.5.1.23 | myristic acid + sphingosine | highest ceramide synthesis activity with myristic acid | Rattus norvegicus | N-myristoylsphingosine + H2O | - |
? | |
3.5.1.23 | N-acylsphingosine + H2O | CDase cleaves the N-acyl linkage of ceramide into sphingosine and free fatty acid, brain CDase is able to catalyze the reverse reaction, i.e. ceramide synthesis | Rattus norvegicus | a carboxylate + sphingosine | - |
r | |
3.5.1.23 | N-palmitoylsphingosine + H2O | - |
Rattus norvegicus | palmitic acid + sphingosine | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.1.23 | CDase | - |
Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.5.1.23 | 6.5 | 7 | ceramide synthesis activity, narrow optimum in the neutral range | Rattus norvegicus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.5.1.23 | 5 | 8 | very low ceramide synthesis activity below pH 5 or above pH 8 | Rattus norvegicus |
3.5.1.23 | 5.5 | 10 | broad pH-range, ceramidase activity | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.23 | additional information | coenzyme A-independent mechanism | Rattus norvegicus |