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Literature summary extracted from

  • Sladek, N.E.
    Human aldehyde dehydrogenases: Potential pathological, pharmacological, and toxicological impact (2003), J. Biochem. Mol. Toxicol., 17, 7-23.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 mitochondrion
-
 Homo sapiens 5739
-
1.2.1.36 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.3 54400
-
 4 * 54400 Homo sapiens
1.2.1.36 54600
-
 4 * 54600 Homo sapiens
1.2.1.36 54700
-
 4 * 54700, calculation from nucleotide sequence Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
-
-
1.2.1.36 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 brain
-
 Homo sapiens
-
1.2.1.3 heart
-
 Homo sapiens
-
1.2.1.3 kidney tissue with highest content Homo sapiens
-
1.2.1.3 lens tissue with highest content Homo sapiens
-
1.2.1.3 liver tissue with highest content Homo sapiens
-
1.2.1.3 lung
-
 Homo sapiens
-
1.2.1.3 pancreas
-
 Homo sapiens
-
1.2.1.3 prostate gland
-
 Homo sapiens
-
1.2.1.3 skeletal muscle
-
 Homo sapiens
-
1.2.1.3 spleen
-
 Homo sapiens
-
1.2.1.36 brain
-
 Homo sapiens
-
1.2.1.36 breast
-
 Homo sapiens
-
1.2.1.36 erythrocyte
-
 Homo sapiens
-
1.2.1.36 kidney
-
 Homo sapiens
-
1.2.1.36 kidney tissue with highest content Homo sapiens
-
1.2.1.36 lens
-
 Homo sapiens
-
1.2.1.36 liver
-
 Homo sapiens
-
1.2.1.36 lung
-
 Homo sapiens
-
1.2.1.36 mucosa
-
 Homo sapiens
-
1.2.1.36 ovary
-
 Homo sapiens
-
1.2.1.36 pancreas
-
 Homo sapiens
-
1.2.1.36 prostate
-
 Homo sapiens
-
1.2.1.36 skeletal muscle
-
 Homo sapiens
-
1.2.1.36 stomach
-
 Homo sapiens
-
1.2.1.36 testis
-
 Homo sapiens
-
1.2.1.36 testis tissue with highest content Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 acetaldehyde + NAD+ + H2O preferred substrate Homo sapiens acetate + NADH + H+
-
 ?
1.2.1.3 chloroacetaldehyde + NAD+ + H2O
-
 Homo sapiens chloroacetate + NADH + H+
-
 ?
1.2.1.36 acetaldehyde + NAD+ + H2O
-
 Homo sapiens acetate + NADH + H+
-
 ?
1.2.1.36 aldophosphoamide + NAD+ + H2O
-
 Homo sapiens ?
-
 ?
1.2.1.36 additional information also active with medium-chain saturated aliphatic aldehydes Homo sapiens ?
-
 ?
1.2.1.36 retinal + NAD+ + H2O preferred substrate Homo sapiens retinoate + NADH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.3 tetramer 4 * 54400 Homo sapiens
1.2.1.36 tetramer 4 * 54600 Homo sapiens
1.2.1.36 tetramer 4 * 54700, calculation from nucleotide sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 ALDH 2
-
 Homo sapiens
1.2.1.36 ALDH 1A1
-
 Homo sapiens
1.2.1.36 ALDH 1A2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens
1.2.1.36 NAD+
-
 Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.2.1.3 Homo sapiens about
-
 4.9
1.2.1.36 Homo sapiens about
-
 4.9