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Literature summary extracted from

  • Fan, F.; Gadda, G.
    On the catalytic mechanism of choline oxidase (2005), J. Am. Chem. Soc., 127, 2067-2074.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.3.17 additional information
-
additional information stopped-flow kinetics Arthrobacter globiformis
1.1.3.17 0.25
-
choline pH 10, 25°C Arthrobacter globiformis
1.1.3.17 0.69
-
O2 pH 10, 25°C, cosubstrate choline Arthrobacter globiformis
1.1.3.17 2.54
-
O2 pH 10, 25°C, cosubstrate betaine aldehyde Arthrobacter globiformis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.3.17 choline + O2 Arthrobacter globiformis FAD-linked reaction betaine aldehyde + H2O2
-
?
1.1.3.17 FADH2 + O2 Arthrobacter globiformis
-
FAD + H2O2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.3.17 Arthrobacter globiformis
-
strain ATCC 8010
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.3.17 choline + O2 = betaine aldehyde + H2O2 choline hydroxyl proton is not in flight in the transition state for CH bond cleavage, steps of flavin reduction by choline and betaine aldehyde is rate rate limiting for the overall turnover Arthrobacter globiformis
1.1.3.17 choline + O2 = betaine aldehyde + H2O2 reaction mechanism via FAD, the enzyme catalyzes the four-electron-oxidation of choline to glycine betaine via the intermediate betaine aldehyde in two sequential FAD-dependent reaction steps, hydride transfer and oxygen radical mechanisms, overview Arthrobacter globiformis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.3.17 betaine aldehyde + O2 + H2O
-
Arthrobacter globiformis betaine + H2O2
-
?
1.1.3.17 choline + O2
-
Arthrobacter globiformis betaine aldehyde + H2O2
-
?
1.1.3.17 choline + O2 FAD-linked reaction Arthrobacter globiformis betaine aldehyde + H2O2
-
?
1.1.3.17 FADH2 + O2
-
Arthrobacter globiformis FAD + H2O2
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.3.17 25
-
assay at Arthrobacter globiformis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.3.17 60
-
choline pH 10, 25°C Arthrobacter globiformis
1.1.3.17 133
-
Betaine aldehyde pH 10, 25°C Arthrobacter globiformis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.3.17 6 10
-
Arthrobacter globiformis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.3.17 FAD dependent on Arthrobacter globiformis