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Literature summary extracted from
- Physiological role of soluble fumarate reductase in redox balancing during anaerobiosis in Saccharomyces cerevisiae (2002), FEMS Microbiol. Lett., 215, 103-108.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.3.1.6 | - |
Saccharomyces cerevisiae |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.3.1.6 | additional information | construction of gene disruption mutants, simultaneous disruption of genes FRDS and OSM1 cause a growth defect mutant under anaerobic conditions, while disruption of gene OSM1 alone leads to a slow growth, both due to lack in cellular NAD+, which can be overcome by addition of methylene blue or phenazine methosulfate which oxidized NADH to NAD+ | Saccharomyces cerevisiae |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.3.1.6 | soluble | - |
Saccharomyces cerevisiae | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.6 | fumarate + NADH + H+ | Saccharomyces cerevisiae | physiological role in redox balancing during anaerobiosis, both isozymes are required for reoxidation of intracellular NADH | succinate + NAD+ | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.1.6 | Saccharomyces cerevisiae | - |
2 isozymes FRDS1 and FRDS2 encoded by gene FRDS and OSM1, respectively | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.6 | fumarate + NADH + H+ | - |
Saccharomyces cerevisiae | succinate + NAD+ | - |
? | |
| 1.3.1.6 | fumarate + NADH + H+ | physiological role in redox balancing during anaerobiosis, both isozymes are required for reoxidation of intracellular NADH | Saccharomyces cerevisiae | succinate + NAD+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.3.1.6 | FRDS | - |
Saccharomyces cerevisiae |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.6 | NADH | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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