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Literature summary extracted from

  • Takacs, E.; Grolmusz, V.K.; Vertessy, B.G.
    A tradeoff between protein stability and conformational mobility in homotrimeric dUTPases (2004), FEBS Lett., 566, 48-54.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.23 Mg2+ required Drosophila melanogaster
3.6.1.23 Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.23 dUTP + H2O Drosophila melanogaster removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O Escherichia coli removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA dUMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.23 Drosophila melanogaster
-
-
-
3.6.1.23 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.23 dUTP + H2O
-
 Drosophila melanogaster dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O
-
 Escherichia coli dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA Drosophila melanogaster dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA Escherichia coli dUMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.23 trimer
-
 Drosophila melanogaster
3.6.1.23 trimer
-
 Escherichia coli

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.6.1.23 53
-
 melting point, increases in the presence of Mg2+ and substrate Drosophila melanogaster
3.6.1.23 74.5
-
 melting point Escherichia coli