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Literature summary extracted from

  • Torres, J.M.; Ortega, E.
    Differential regulation of steroid 5alpha-reductase isozymes expression by androgens in the adult rat brain (2003), FASEB J., 17, 1428-1433.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.99.5 additional information expression of isozyme 5alpha-R2 is induced by testosterone and dihydrotestosterone Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.99.5 quantitative expression analysis of isozymes 5alpha-R1 and 5alpha-R2 in brain Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.99.5 additional information expression of isozyme 5alpha-R1 is inhibited by testosterone and dihydrotestosterone Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.99.5 deoxycorticosterone + reduced acceptor Rattus norvegicus
-
 21-hydroxy-5alpha-pregnan-3,20-dione + acceptor
-
 ?
1.3.99.5 additional information Rattus norvegicus the enzyme produces precursors for the biosynthesis of allopregnenolone and tetrahydrodeoxycorticosterone, physiological role of the isozymes in the brain, overview ?
-
 ?
1.3.99.5 progesterone + reduced acceptor Rattus norvegicus
-
 pregnane-3,20-dione + acceptor
-
 ?
1.3.99.5 testosterone + reduced acceptor Rattus norvegicus
-
 5alpha-dihydrotestosterone + acceptor 5alpha-dihydrotestosterone is a more potent androgen ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.99.5 Rattus norvegicus
-
 male Wistar rats, 2 isozymes 5alpha-R1 and 5alpha-R2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.99.5 brain adult, isozymes 5alpha-R1 and 5alpha-R2 Rattus norvegicus
-
1.3.99.5 cerebral cortex prefrontal, expression of isozymes 5alpha-R1 and 5alpha-R2 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.99.5 deoxycorticosterone + reduced acceptor
-
 Rattus norvegicus 21-hydroxy-5alpha-pregnan-3,20-dione + acceptor
-
 ?
1.3.99.5 additional information the enzyme produces precursors for the biosynthesis of allopregnenolone and tetrahydrodeoxycorticosterone, physiological role of the isozymes in the brain, overview Rattus norvegicus ?
-
 ?
1.3.99.5 progesterone + reduced acceptor
-
 Rattus norvegicus pregnane-3,20-dione + acceptor
-
 ?
1.3.99.5 testosterone + reduced acceptor
-
 Rattus norvegicus 5alpha-dihydrotestosterone + acceptor
-
 ?
1.3.99.5 testosterone + reduced acceptor
-
 Rattus norvegicus 5alpha-dihydrotestosterone + acceptor 5alpha-dihydrotestosterone is a more potent androgen ?

Synonyms

EC Number Synonyms Comment Organism
1.3.99.5 5alpha-R
-
 Rattus norvegicus
1.3.99.5 steroid 5alpha-reductase
-
 Rattus norvegicus