EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.37 | overexpression in Escherichia coli | Plasmodium falciparum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.37 | gossypol | IC50: 0.0115 mM | Plasmodium falciparum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.37 | 0.022 | - |
acetylpyridine adenine dinucleotide | pH 7.5 | Plasmodium falciparum | |
1.1.1.37 | 0.03 | - |
oxaloacetate | pH 7.5 | Plasmodium falciparum | |
1.1.1.37 | 0.036 | - |
NADH | pH 7.5 | Plasmodium falciparum | |
1.1.1.37 | 0.152 | - |
NAD+ | pH 10.2 | Plasmodium falciparum | |
1.1.1.37 | 0.37 | - |
reduced acetylpyridine adenine dinucleotide | pH 10.2 | Plasmodium falciparum | |
1.1.1.37 | 1.35 | - |
malate | pH 10.2 | Plasmodium falciparum | |
1.1.1.37 | 5.44 | - |
alpha-ketomalonate | pH 7.5 | Plasmodium falciparum |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.37 | Plasmodium falciparum | Q6VVP7 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.37 | schizont | high protein level | Plasmodium falciparum | - |
1.1.1.37 | trophozoite | highest level of transcript, high protein level | Plasmodium falciparum | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.37 | (S)-malate + acetylpyridine adenine dinucleotide | - |
Plasmodium falciparum | oxaloacetate + reduced acetylpyridine adenine dinucleotide | - |
? | |
1.1.1.37 | (S)-malate + NAD+ | - |
Plasmodium falciparum | oxaloacetate + NADH + H+ | - |
r | |
1.1.1.37 | alpha-ketomalonate + NADH | - |
Plasmodium falciparum | ? | - |
? | |
1.1.1.37 | malate + NAD+ | - |
Plasmodium falciparum | oxaloacetate + NADH + H+ | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.37 | 150 | - |
NAD+ | pH 10.2 | Plasmodium falciparum | |
1.1.1.37 | 175 | - |
reduced acetylpyridine adenine dinucleotide | pH 10.2 | Plasmodium falciparum | |
1.1.1.37 | 250 | - |
malate | pH 10.2 | Plasmodium falciparum | |
1.1.1.37 | 674 | - |
alpha-ketomalonate | pH 7.5 | Plasmodium falciparum | |
1.1.1.37 | 950 | - |
NADH | pH 7.5 | Plasmodium falciparum | |
1.1.1.37 | 960 | - |
oxaloacetate | pH 7.5 | Plasmodium falciparum | |
1.1.1.37 | 1010 | - |
acetylpyridine adenine dinucleotide | pH 7.5 | Plasmodium falciparum |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.37 | additional information | cannot use NADP+ and NADPH as cofactor | Plasmodium falciparum | |
1.1.1.37 | NAD+ | - |
Plasmodium falciparum | |
1.1.1.37 | NADH | - |
Plasmodium falciparum |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.1.37 | 0.0115 | - |
IC50: 0.0115 mM | Plasmodium falciparum | gossypol |