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Literature summary extracted from

  • Kang, J.H.; Hong, M.L.; Kim, D.W.; Park, J.; Kang, T.C.; Won, M.H.; Baek, N.I.; Moon, B.J.; Choi, S.Y.; Kwon, O.S.
    Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase (2004), Eur. J. Biochem., 271, 2452-2461.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.5 expression in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.4.3.5 DELTA1-56 3.35fold increase in KM-value for pyridoxamine 5'-phosphate compared to wild-type enzyme, 2.95fold increase in KM-value for pyridoxine 5'-phosphate compared to wild-type enzyme, 6fold increase in KI-value for pyridoxal 5'-phosphate compared to wild-type enzyme Homo sapiens
1.4.3.5 DELTA238-262 inactive mutant enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.5 pyridoxal 5'-phosphate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.5 0.0021
-
 pyridoxamine 5'-phosphate pH 8.0, 25°C, wild-type enzyme Homo sapiens
1.4.3.5 0.0062
-
 pyridoxine 5'-phosphate pH 8.0, 25°C, wild-type enzyme Homo sapiens
1.4.3.5 0.0062
-
 pyridoxamine 5'-phosphate pH 8.0, 25°C, mutant enzyme DELTA1-56 Homo sapiens
1.4.3.5 0.0208
-
 pyridoxine 5'-phosphate pH 8.0, 25°C, mutant enzyme DELTA1-56 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.5 A-549 cell 0.7% of the activity in liver Homo sapiens
-
1.4.3.5 adrenal gland 11.5% of the activity in liver Homo sapiens
-
1.4.3.5 amygdala 13.0% of the activity in liver Homo sapiens
-
1.4.3.5 aorta 1.2% of the activity in liver Homo sapiens
-
1.4.3.5 atrium 14% of the activity in liver detected in left atrium, 11.6% of the activity in liver detected in tight atrium Homo sapiens
-
1.4.3.5 bladder 6.8% of the activity in liver Homo sapiens
-
1.4.3.5 bone marrow 11.2% of the activity in liver Homo sapiens
-
1.4.3.5 brain 23.8% of the activity in liver Homo sapiens
-
1.4.3.5 caudate nucleus 19.0% of the activity in liver Homo sapiens
-
1.4.3.5 caudate putamen 2.0% of the activity in liver Homo sapiens
-
1.4.3.5 cerebellum 13.3% of the activity in liver detected in left cerebellum, 25.0% of the activity in liver detected in the right cerebellum Homo sapiens
-
1.4.3.5 cerebral cortex 25.9% of the activity in liver Homo sapiens
-
1.4.3.5 cerebral gyrus of cerebral cortex, 9.5% of the activity in liver Homo sapiens
-
1.4.3.5 colon 1.2% of the activity in liver detected in ascending colon, 7.9% of the activity in liver is detected in transverse colon, 2.8% of the activity in liver is detected in descending colon Homo sapiens
-
1.4.3.5 corpus callosum 18.4% of the activity in liver Homo sapiens
-
1.4.3.5 DAUDI cell 1.1% of the activity in liver Homo sapiens
-
1.4.3.5 duodenum 9.3% of the activity in liver Homo sapiens
-
1.4.3.5 esophagus 7.5% of the activity in liver Homo sapiens
-
1.4.3.5 frontal lobe 12.4% of the activity in liver Homo sapiens
-
1.4.3.5 heart 3.7% of the activity in liver Homo sapiens
-
1.4.3.5 HeLa-S3 cell 3.5% of the activity in liver Homo sapiens
-
1.4.3.5 hippocampus 12.3% of the activity in liver Homo sapiens
-
1.4.3.5 HL-60 cell 2.3% of the activity in liver Homo sapiens
-
1.4.3.5 ileocecum 6.1% of the activity in liver Homo sapiens
-
1.4.3.5 ileum 5.8% of the activity in liver Homo sapiens
-
1.4.3.5 interventricular septum 16.2% of the activity in liver Homo sapiens
-
1.4.3.5 jejunum 13.3% of the activity in liver Homo sapiens
-
1.4.3.5 K-562 cell 2.5% of the activity in liver Homo sapiens
-
1.4.3.5 kidney 85.6% of the activity in liver Homo sapiens
-
1.4.3.5 left ventricle 4.1% of the activity in liver detected in the left ventricle Homo sapiens
-
1.4.3.5 leukocyte from peripheral blood, 0.4% of the activity in liver Homo sapiens
-
1.4.3.5 liver 30.2% of the activity of adult liver is detected in foetal liver Homo sapiens
-
1.4.3.5 lung 4.6% of the activity in liver Homo sapiens
-
1.4.3.5 lymph node 4.6% of the activity in liver Homo sapiens
-
1.4.3.5 medulla oblongata 5.0% of the activity in liver Homo sapiens
-
1.4.3.5 MOLT-4 cell 8.1% of the activity in liver Homo sapiens
-
1.4.3.5 nucleus accumbens 5.2% of the activity in liver Homo sapiens
-
1.4.3.5 occipital lobe 14.7% of the activity in liver Homo sapiens
-
1.4.3.5 ovary 4.3% of the activity in liver Homo sapiens
-
1.4.3.5 pancreas 2.5% of the activity in liver Homo sapiens
-
1.4.3.5 parietal lobe 13.6% of the activity in liver Homo sapiens
-
1.4.3.5 placenta 30.2% of the activity in liver Homo sapiens
-
1.4.3.5 pons 6.2% of the activity in liver Homo sapiens
-
1.4.3.5 prostate gland 16.5% of the activity in liver Homo sapiens
-
1.4.3.5 RAJI cell 6.5% of the activity in liver Homo sapiens
-
1.4.3.5 rectum 2.3% of the activity in liver Homo sapiens
-
1.4.3.5 right ventricle 20.5% of the activity in liver detected in the right ventricle Homo sapiens
-
1.4.3.5 salivary gland 10% of the activity in liver Homo sapiens
-
1.4.3.5 skeletal muscle 34.1% of the activity in liver Homo sapiens
-
1.4.3.5 spinal cord 1.6% of the activity in liver Homo sapiens
-
1.4.3.5 spleen 13.5% of the activity in liver Homo sapiens
-
1.4.3.5 stomach 17.2% of the activity in liver Homo sapiens
-
1.4.3.5 SW-480 cell 5.1% of the activity in liver Homo sapiens
-
1.4.3.5 temporal lobe 12.6% of the activity in liver Homo sapiens
-
1.4.3.5 testis 8.4% of the activity in liver Homo sapiens
-
1.4.3.5 thalamus 10.8% of the activity in liver Homo sapiens
-
1.4.3.5 thymus 6.4% of the activity in liver Homo sapiens
-
1.4.3.5 thyroid gland 20.3% of the activity in liver Homo sapiens
-
1.4.3.5 trachea 4.8% of the activity in liver Homo sapiens
-
1.4.3.5 uterus 2.9% of the activity in liver Homo sapiens
-
1.4.3.5 vermiform appendix 0.7% of the activity in liver Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.5 pyridoxamine 5'-phosphate + H2O + O2
-
 Homo sapiens pyridoxal 5'-phosphate + NH3 + H2O2
-
 ?
1.4.3.5 pyridoxine 5'-phosphate + H2O + O2
-
 Homo sapiens pyridoxal 5'-phosphate + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.5 PNPO
-
 Homo sapiens
1.4.3.5 pyridoxine 5'-phosphate oxidase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.5 3.8
-
 pyridoxal 5'-phosphate pH 8.5, 25°C, pyridoxine 5'-phosphate as substrate, wild-type enzyme Homo sapiens
1.4.3.5 23
-
 pyridoxal 5'-phosphate pH 8.5, 25°C, pyridoxine 5'-phosphate as substrate, mutant enzyme DELTA1-56 Homo sapiens