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Literature summary extracted from

  • Martras, S.; Alvarez, R.; Martinez, S.E.; Torres, D.; Gallego, O.; Duester, G.; Farres, J.; de Lera, A.R.; Pares, X.
    The specificity of alcohol dehydrogenase with cis-retinoids. Activity with 11-cis-retinol and localization in retina (2004), Eur. J. Biochem., 271, 1660-1670.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.1 expression of isozymes in Escherichia coli strain BL21 Mus musculus
1.1.1.1 expression of isozymes in Escherichia coli strain BL21 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.1 additional information
-
 additional information Km for isozymes ADH1, and ADH4 for all retinoid substrates in forward and reverse reaction Mus musculus
1.1.1.1 additional information
-
 additional information Km for isozymes ADH1B1, ADH1B2, and ADH4 for all retinoid substrates in forward and reverse reaction Homo sapiens
1.1.1.1 0.006
-
 Hexanol recombinant isozyme ADH4, pH 7.5, 25°C Mus musculus
1.1.1.1 0.011
-
 9-cis-retinol isozyme ADH1B1, pH 7.5, 25°C Homo sapiens
1.1.1.1 0.018
-
 11-cis-retinol isozyme ADH1B2, pH 7.5, 25°C Homo sapiens
1.1.1.1 0.023
-
 9-cis-retinol isozyme ADH1B2, pH 7.5, 25°C Homo sapiens
1.1.1.1 0.03
-
 all-trans-retinol isozyme ADH1B1, pH 7.5, 25°C Homo sapiens
1.1.1.1 0.033
-
 all-trans-retinol isozyme ADH1B2, pH 7.5, 25°C Homo sapiens
1.1.1.1 0.035
-
 11-cis-retinol isozyme ADH1B1, pH 7.5, 25°C Homo sapiens
1.1.1.1 0.085
-
 Hexanol recombinant isozyme ADH1, pH 7.5, 25°C Mus musculus
1.1.1.1 0.48
-
 ethanol recombinant isozyme ADH1, pH 7.5, 25°C Mus musculus
1.1.1.1 0.63
-
 Hexanol recombinant isozyme ADH4, pH 10.5, 25°C Mus musculus
1.1.1.1 0.83
-
 ethanol recombinant isozyme ADH1, pH 10.5, 25°C Mus musculus
1.1.1.1 1.9
-
 Hexanol recombinant isozyme ADH1, pH 10.5, 25°C Mus musculus
1.1.1.1 255
-
 ethanol recombinant isozyme ADH4, pH 10.5, 25°C Mus musculus
1.1.1.1 1625
-
 ethanol recombinant isozyme ADH4, pH 7.5, 25°C Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.1 Zn2+ 1 catalytic and 1 structural zinc ion per subunit Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.1 Homo sapiens
-
 isozymes ADH1B1, ADH1B2, and ADH4
-
1.1.1.1 Mus musculus
-
 isozymes ADH1 and ADH4
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.1 recombinant isozymes from Escherichia coli strain BL21 Mus musculus
1.1.1.1 recombinant isozymes from Escherichia coli strain BL21 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.1 retina isozyme ADH4 Mus musculus
-
1.1.1.1 retina isozyme ADH4 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.1 11-cis-retinol + NAD+
-
 Mus musculus 11-cis-retinal + NADH
-
 ?
1.1.1.1 11-cis-retinol + NAD+
-
 Homo sapiens 11-cis-retinal + NADH
-
 ?
1.1.1.1 13-cis-retinol + NAD+ no activity with isozyme ADH1 Mus musculus 13-cis-retinal + NADH
-
 ?
1.1.1.1 13-cis-retinol + NAD+ no activity with isozyme ADH1 Homo sapiens 13-cis-retinal + NADH
-
 ?
1.1.1.1 7-cis-retinol + NAD+
-
 Mus musculus 7-cis-retinal + NADH
-
 ?
1.1.1.1 7-cis-retinol + NAD+
-
 Homo sapiens 7-cis-retinal + NADH
-
 ?
1.1.1.1 9-cis-retinol + NAD+
-
 Mus musculus 9-cis-retinal + NADH
-
 ?
1.1.1.1 9-cis-retinol + NAD+
-
 Homo sapiens 9-cis-retinal + NADH
-
 ?
1.1.1.1 all-trans-retinol + NAD+
-
 Mus musculus all-trans-retinal + NADH
-
 ?
1.1.1.1 all-trans-retinol + NAD+
-
 Homo sapiens all-trans-retinal + NADH
-
 ?
1.1.1.1 ethanol + NAD+
-
 Mus musculus acetaldehyde + NADH
-
 ?
1.1.1.1 ethanol + NAD+
-
 Homo sapiens acetaldehyde + NADH
-
 ?
1.1.1.1 hexanol + NAD+
-
 Mus musculus hexaldehyde + NADH
-
 ?
1.1.1.1 hexanol + NAD+
-
 Homo sapiens hexanal + NADH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.1 ADH
-
 Mus musculus
1.1.1.1 ADH
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.1 25
-
 assay at Mus musculus
1.1.1.1 25
-
 assay at Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.1 additional information
-
 additional information kcat for isozymes ADH1, and ADH4 for all retinoid substrates in forward and reverse reaction Mus musculus
1.1.1.1 additional information
-
 additional information kcat for isozymes ADH1B1, ADH1B2, and ADH4 for all retinoid substrates in forward and reverse reaction Homo sapiens
1.1.1.1 0.45
-
 Hexanol recombinant isozyme ADH1, pH 7.5, 25°C Mus musculus
1.1.1.1 1.92
-
 ethanol recombinant isozyme ADH1, pH 7.5, 25°C Mus musculus
1.1.1.1 3.83
-
 Hexanol recombinant isozyme ADH1, pH 10.5, 25°C Mus musculus
1.1.1.1 4.42
-
 ethanol recombinant isozyme ADH1, pH 10.5, 25°C Mus musculus
1.1.1.1 30.8
-
 Hexanol recombinant isozyme ADH4, pH 7.5, 25°C Mus musculus
1.1.1.1 41.3
-
 ethanol recombinant isozyme ADH4, pH 7.5, 25°C Mus musculus
1.1.1.1 86.5
-
 Hexanol recombinant isozyme ADH4, pH 10.5, 25°C Mus musculus
1.1.1.1 215
-
 ethanol recombinant isozyme ADH4, pH 10.5, 25°C Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.1 8.5
-
 isozyme ADH1B2, assay at Homo sapiens
1.1.1.1 10.5
-
 assay at Mus musculus
1.1.1.1 10.5
-
 isozyme ADH1B1, ADH4, assay at Homo sapiens