BRENDA - Enzyme Database

Inactivation of copper-containing amine oxidases by turnover products

Pietrangeli, P.; Nocera, S.; Federico, R.; Mondovi, B.; Morpurgo, L.; Eur. J. Biochem. 271, 146-152 (2004)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.4.3.22
H2O2
inactivation by turnover products is a slow reaction of the reduced protein with H2O2 subsequent to turnover and occurs in a similar way for all amines
Lathyrus cicera
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.4.3.22
Lathyrus cicera
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
1.4.3.22
-
Lathyrus cicera
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.4.3.22
70
-
-
Lathyrus cicera
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.4.3.22
2-aminomethylpyridine + H2O + O2
-
655478
Lathyrus cicera
pyridinaldehyde + NH3 + H2O2
-
-
-
?
1.4.3.22
agmatine + H2O + O2
-
655478
Lathyrus cicera
?
-
-
-
?
1.4.3.22
benzylamine + H2O + O2
-
655478
Lathyrus cicera
benzaldehyde + NH3 + H2O2
-
-
-
?
1.4.3.22
cadaverine + H2O + O2
-
655478
Lathyrus cicera
?
-
-
-
?
1.4.3.22
histamine + H2O + O2
-
655478
Lathyrus cicera
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
1.4.3.22
putrescine + H2O + O2
-
655478
Lathyrus cicera
?
-
-
-
?
1.4.3.22
spermidine + H2O + O2
-
655478
Lathyrus cicera
?
-
-
-
?
1.4.3.22
spermine + H2O + O2
-
655478
Lathyrus cicera
?
-
-
-
?
1.4.3.22
tyramine + H2O + O2
-
655478
Lathyrus cicera
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
Turnover Number [1/s]
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1.4.3.22
0.47
-
2-aminomethylpyridine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
3.7
-
benzylamine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
10.3
-
histamine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
28.3
-
spermine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
32.9
-
tyramine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
45.9
-
agmatine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
100
-
spermidine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
159
-
cadaverine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
262
-
putrescine
pH 7.2, 25°C
Lathyrus cicera
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.4.3.22
H2O2
inactivation by turnover products is a slow reaction of the reduced protein with H2O2 subsequent to turnover and occurs in a similar way for all amines
Lathyrus cicera
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.4.3.22
-
Lathyrus cicera
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.4.3.22
70
-
-
Lathyrus cicera
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.4.3.22
2-aminomethylpyridine + H2O + O2
-
655478
Lathyrus cicera
pyridinaldehyde + NH3 + H2O2
-
-
-
?
1.4.3.22
agmatine + H2O + O2
-
655478
Lathyrus cicera
?
-
-
-
?
1.4.3.22
benzylamine + H2O + O2
-
655478
Lathyrus cicera
benzaldehyde + NH3 + H2O2
-
-
-
?
1.4.3.22
cadaverine + H2O + O2
-
655478
Lathyrus cicera
?
-
-
-
?
1.4.3.22
histamine + H2O + O2
-
655478
Lathyrus cicera
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
1.4.3.22
putrescine + H2O + O2
-
655478
Lathyrus cicera
?
-
-
-
?
1.4.3.22
spermidine + H2O + O2
-
655478
Lathyrus cicera
?
-
-
-
?
1.4.3.22
spermine + H2O + O2
-
655478
Lathyrus cicera
?
-
-
-
?
1.4.3.22
tyramine + H2O + O2
-
655478
Lathyrus cicera
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
Turnover Number [1/s] (protein specific)
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1.4.3.22
0.47
-
2-aminomethylpyridine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
3.7
-
benzylamine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
10.3
-
histamine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
28.3
-
spermine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
32.9
-
tyramine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
45.9
-
agmatine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
100
-
spermidine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
159
-
cadaverine
pH 7.2, 25°C
Lathyrus cicera
1.4.3.22
262
-
putrescine
pH 7.2, 25°C
Lathyrus cicera