EC Number | Application | Comment | Organism |
---|---|---|---|
4.6.1.12 | medicine | the enzyme is a potential target for antimalarial drugs directed at the nonmevalonate pathway of isoprenoid biosynthesis | Plasmodium falciparum |
EC Number | Cloned (Comment) | Organism |
---|---|---|
4.6.1.12 | expression in Escherichia coli | Plasmodium falciparum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.12 | EDTA | 5 mM. Activity can be restored by the addition of Mg2+ to a concentration of 10 mM | Plasmodium falciparum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.6.1.12 | 0.252 | - |
4-diphosphocytidyl-2C-methyl-D-erythritol | pH 7.0, 27°C | Plasmodium falciparum |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.12 | Mg2+ | Mg2+ or Mn2+ are required | Plasmodium falciparum | |
4.6.1.12 | Mn2+ | Mg2+ or Mn2+ are required | Plasmodium falciparum |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
4.6.1.12 | 21348 | - |
x * 21348, electrospray mass spectrometry | Plasmodium falciparum |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.12 | 2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol | Plasmodium falciparum | nonmevalonate pathway of isoprenoid biosynthesis | 2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.6.1.12 | Plasmodium falciparum | P62368 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.6.1.12 | - |
Plasmodium falciparum |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
4.6.1.12 | 0.75 | - |
- |
Plasmodium falciparum |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.12 | 2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol | - |
Plasmodium falciparum | 2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP | - |
? | |
4.6.1.12 | 2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol | at low rate | Plasmodium falciparum | 2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP | - |
? | |
4.6.1.12 | 2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol | nonmevalonate pathway of isoprenoid biosynthesis | Plasmodium falciparum | 2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP | - |
? | |
4.6.1.12 | 4-diphosphocytidyl-2C-methyl-D-erythritol | at low rate | Plasmodium falciparum | 2C-methyl-D-erythritol 3,4-cyclophosphate + CMP | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
4.6.1.12 | ? | x * 21348, electrospray mass spectrometry | Plasmodium falciparum |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.6.1.12 | 7 | - |
- |
Plasmodium falciparum |