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Literature summary extracted from

  • Waddell, B.J.; Hisheh, S.; Krozowski, Z.S.; Burton, P.J.
    Localization of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in the male reproductive tract (2003), Endocrinology, 144, 3101-3106.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 corticosterone + NAD+ Rattus norvegicus
-
 11-dehydrocorticosterone + NADH + H+
-
 ir
1.1.1.146 11-dehydrocorticosterone + NADPH Rattus norvegicus predominantly a reductase in vivo corticosterone + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Rattus norvegicus
-
-
-
1.1.1.146 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 corpus cavernosum of the penis Rattus norvegicus
-
1.1.1.B40 epididymis epithelium Rattus norvegicus
-
1.1.1.146 blood vessel
-
 Rattus norvegicus
-
1.1.1.146 caput epididymis
-
 Rattus norvegicus
-
1.1.1.146 cauda epididymis
-
 Rattus norvegicus
-
1.1.1.146 epithelium of the vas defernes Rattus norvegicus
-
1.1.1.146 liver
-
 Rattus norvegicus
-
1.1.1.146 penile urethra
-
 Rattus norvegicus
-
1.1.1.146 penis
-
 Rattus norvegicus
-
1.1.1.146 seminal vesicle
-
 Rattus norvegicus
-
1.1.1.146 smooth muscle of the vas deferens and penile blood vessels Rattus norvegicus
-
1.1.1.146 testis
-
 Rattus norvegicus
-
1.1.1.146 vas deferens epithelium Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 corticosterone + NAD+
-
 Rattus norvegicus 11-dehydrocorticosterone + NADH + H+
-
 ir
1.1.1.146 11-dehydrocorticosterone + NADPH predominantly a reductase in vivo Rattus norvegicus corticosterone + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-HSD2
-
 Rattus norvegicus
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 2
-
 Rattus norvegicus
1.1.1.146 11beta-HSD1
-
 Rattus norvegicus
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Rattus norvegicus