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Literature summary extracted from

  • Wang, G.M.; Ge, R.S.; Latif, S.A.; Morris, D.J.; Hardy, M.P.
    Expression of 11beta-hydroxylase in rat Leydig cells (2002), Endocrinology, 143, 621-626.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 11-oxoandrosterone 0.0021 mM, 50% inhibition of oxido-reductase reaction Rattus norvegicus
1.1.1.146 11-oxoprogesterone 0.0095 mM, 50% inhibition of oxido-reductase reaction Rattus norvegicus
1.1.1.146 11-oxotestosterone 0.018 mM, 50% inhibition of oxido-reductase reaction Rattus norvegicus
1.1.1.146 11beta-hydroxyandrosterone 0.07 mM, 50% inhibition of dehydrogenase reaction Rattus norvegicus
1.1.1.146 11beta-hydroxydehydroepiandrosterone 0.003 mM, 50% inhibition of dehydrogenase reaction Rattus norvegicus
1.1.1.146 11beta-hydroxyprogesterone 0.0004 mM, 50% inhibition of dehydrogenase reaction Rattus norvegicus
1.1.1.146 11beta-hydroxytestosterone 0.0017 mM, 50% inhibition of dehydrogenase reaction Rattus norvegicus
1.1.1.146 testosterone 0.003 mM, 50% inhibition of oxido-reductase reaction; 0.02 mM, 50% inhibition of dehydrogenase reaction Rattus norvegicus
1.14.15.4 11beta-hydroxy-dehydroepiandrosterone 50% inhibition at 0.0033 mM Rattus norvegicus
1.14.15.4 11beta-hydroxy-progesterone 50% inhibition at 0.0004 mM Rattus norvegicus
1.14.15.4 11beta-hydroxy-testosterone 50% inhibition at 0.0017 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.146 0.0073
-
 11-Dehydrocorticosterone 37°C, pH 7.4 Rattus norvegicus
1.14.15.4 0.0073
-
 11-deoxycorticosterone 37°C Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.146 51500
-
 x * 51500, immunoblot Rattus norvegicus
1.14.15.4 51500
-
 x * 51500, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 11-dehydrocorticosterone + NADPH Rattus norvegicus
-
 corticosterone + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Rattus norvegicus
-
-
-
1.14.15.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 kidney
-
 Rattus norvegicus
-
1.1.1.146 Leydig cell
-
 Rattus norvegicus
-
1.1.1.146 testis
-
 Rattus norvegicus
-
1.14.15.4 Leydig cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 11-dehydrocorticosterone + NADPH
-
 Rattus norvegicus corticosterone + NADP+
-
 r
1.14.15.4 11-deoxycorticosterone + NADPH + O2
-
 Rattus norvegicus 18-hydroxycorticosterone + NADP+ + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.146 ? x * 51500, immunoblot Rattus norvegicus
1.14.15.4 ? x * 51500, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-HSD1
-
 Rattus norvegicus
1.1.1.146 11beta-hydroxysteroid dehydrogenase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.4 NADPH
-
 Rattus norvegicus