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Literature summary extracted from

  • Lewis, H.A.; Buchanan, S.G.; Burley, S.K.; Conners, K.; Dickey, M.; Dorwart, M.; Fowler, R.; Gao, X.; Guggino, W.B.; Hendrickson, W.A.; Hunt, J.F.; Kearins, M.C.; Lorimer, D.; Maloney, P.C.; Post, K.W.; Rajashankar, K.R.; Rutter, M.E.; Sauder, J.M.; Shriver, S.; Thibodeau, P.H.; Thomas, P.J.; Zhang, M.; Zhao, X.; Emtage, S.
    Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator (2004), EMBO J., 23, 282-293.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.6 expression of wild-type nucleotide-binding domain 1 und a mutated version, K464A, in Escherichia coli Mus musculus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.6.1.6 native and selenomethionyl nucleotide-binding domain 1, hanging-drop vapor-diffusion method Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel Mus musculus the enzyme is an ATP-binding cassette transporter that functions as a chloride channel. Channel gating occurs through ATP binding in an nucleotide-binding domain 1-nucleotide-binding domain 2 nucleotide sandwich that forms upon displacement of nucleotide-binding domain 1 regulatory segments ADP + phosphate + open Cl- channel
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.6 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.6.1.6
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel the enzyme is an ATP-binding cassette transporter that functions as a chloride channel. Channel gating occurs through ATP binding in an nucleotide-binding domain 1-nucleotide-binding domain 2 nucleotide sandwich that forms upon displacement of nucleotide-binding domain 1 regulatory segments Mus musculus ADP + phosphate + open Cl- channel
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.6 CFTR
-
 Mus musculus
5.6.1.6 cystic fibrosis transmembrane conductance regulator
-
 Mus musculus