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Literature summary extracted from

  • Wendt, T.G.; Volkmann, N.; Skiniotis, G.; Goldie, K.N.; Muller, J.; Mandelkow, E.; Hoenger, A.
    Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd (2002), EMBO J., 21, 5969-5978.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.4 Drosophila melanogaster
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Reaction

EC Number Reaction Comment Organism Reaction ID
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) mechanism, model of movement Drosophila melanogaster
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.4 additional information binding geometry between enzyme motor and microtubule which places the motor ahead of its cargo in the minus-end direction, after the uptake of ATP, the two heads rearrange their position relative to each other in a way that promotes a swing of the neck in the minus-end direction Drosophila melanogaster ?
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