Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Manzer, R.; Qamar, L.; Estey, T.; Pappa, A.; Petersen, D.R.; Vasiliou, V.
    Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA (2003), DNA Cell Biol., 22, 329-338.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.3 expression by a baculovirus system Homo sapiens
1.2.1.3 expression by a baculovirus system Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.3 0.0021
-
 4-hydroxynonenal pH 8.0, 25°C Oryctolagus cuniculus
1.2.1.3 0.0035
-
 hexanal pH 8.0, 25°C Oryctolagus cuniculus
1.2.1.3 0.0134
-
 hexanal pH 8.0, 25°C Homo sapiens
1.2.1.3 0.014
-
 malondialdehyde pH 8.0, 25°C Oryctolagus cuniculus
1.2.1.3 0.0179
-
 4-hydroxynonenal pH 8.0, 25°C Homo sapiens
1.2.1.3 0.0662
-
 propionaldehyde pH 8.0, 25°C Oryctolagus cuniculus
1.2.1.3 0.1144
-
 malondialdehyde pH 8.0, 25°C Homo sapiens
1.2.1.3 0.1372
-
 propionaldehyde pH 8.0, 25°C Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.3 54000
-
 x * 54000, SDS-PAGE Homo sapiens
1.2.1.3 54000
-
 x * 54000, SDS-PAGE Oryctolagus cuniculus
1.2.1.3 54340
-
 x * 54340, calculation from nucleotide sequence Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.3 additional information Homo sapiens the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation ?
-
 ?
1.2.1.3 additional information Oryctolagus cuniculus the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
-
-
1.2.1.3 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.3
-
 Homo sapiens
1.2.1.3
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 corneal epithelium
-
 Homo sapiens
-
1.2.1.3 corneal epithelium
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.3 0.2341
-
 substrate: propionaldehyde, pH 8.0, 25°C Homo sapiens
1.2.1.3 0.5337
-
 substrate: propionaldehyde, pH 8.0, 25°C Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 4-hydroxynonenal + NAD+ + H2O
-
 Oryctolagus cuniculus 4-hydroxynonanoate + NADH
-
 ?
1.2.1.3 4-hydroxynonenal + NAD+ + H2O
-
 Homo sapiens 4-hydroxynonanoate + NADH + H+
-
 ?
1.2.1.3 hexanal + NAD+ + H2O
-
 Homo sapiens hexanoate + NADH + H+
-
 ?
1.2.1.3 hexanal + NAD+ + H2O
-
 Oryctolagus cuniculus hexanoate + NADH + H+
-
 ?
1.2.1.3 malondialdehyde + NAD+ + H2O
-
 Homo sapiens ? + NADH
-
 ?
1.2.1.3 malondialdehyde + NAD+ + H2O
-
 Oryctolagus cuniculus ? + NADH
-
 ?
1.2.1.3 additional information the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation Homo sapiens ?
-
 ?
1.2.1.3 additional information the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation Oryctolagus cuniculus ?
-
 ?
1.2.1.3 propanal + NAD+ + H2O
-
 Oryctolagus cuniculus propionate + NADH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.3 ? x * 54000, SDS-PAGE Homo sapiens
1.2.1.3 ? x * 54000, SDS-PAGE Oryctolagus cuniculus
1.2.1.3 ? x * 54340, calculation from nucleotide sequence Oryctolagus cuniculus

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 ALDH1A1
-
 Homo sapiens
1.2.1.3 ALDH1A1
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens
1.2.1.3 NAD+
-
 Oryctolagus cuniculus