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Literature summary extracted from
- Catalysis in the nitrilase superfamily (2002), Curr. Opin. Struct. Biol., 12, 775-782.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.12 | Homo sapiens | - |
- |
- |
| 3.5.5.1 | Arabidopsis thaliana | P32961 | isozyme NIT1 | - |
| 3.5.5.1 | Homo sapiens | Q86X76 | - |
- |
| 3.5.5.7 | Arabidopsis thaliana | P46011 | gene nit4, enzyme Nit4 | - |
| 3.5.5.7 | Rhodococcus rhodochrous | Q03217 | gene nitA | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.5.5.1 | a nitrile + 2 H2O = a carboxylate + NH3 | enzyme structure and reaction mechanism | Arabidopsis thaliana | |
| 3.5.5.1 | a nitrile + 2 H2O = a carboxylate + NH3 | enzyme structure and reaction mechanism | Homo sapiens | |
| 3.5.5.7 | R-CN + 2 H2O = R-COOH + NH3 | enzyme structure and reaction mechanism | Arabidopsis thaliana | |
| 3.5.5.7 | R-CN + 2 H2O = R-COOH + NH3 | enzyme structure, covalent mechanism, formation of an enzyme-thioimidate intermediate rather than addition of water to the nitrile | Rhodococcus rhodochrous |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.12 | biocytin + H2O | the enzyme belongs to the nitrilase superfamily | Homo sapiens | biotin + L-lysine | - |
? |  |
| 3.5.5.1 | phenylpropionitrile + 2 H2O | - |
Arabidopsis thaliana | phenylpropionic acid + NH3 | - |
? | |
| 3.5.5.7 | acrylonitrile + H2O | - |
Rhodococcus rhodochrous | acrylate + NH3 | - |
? | |
| 3.5.5.7 | beta-cyano-L-alanine + H2O | - |
Arabidopsis thaliana | asparagine + aspartic acid | 60:40 mixture | ? | |
| 3.5.5.7 | additional information | lack of acide amide production | Rhodococcus rhodochrous | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.5.1 | auxin-producing nitrilase | - |
Arabidopsis thaliana |
| 3.5.5.1 | humanNIT1 | - |
Homo sapiens |
| 3.5.5.1 | More | enzyme belong to branch 10 of the nitrilase superfamily, overview | Homo sapiens |
| 3.5.5.1 | More | the enzyme belong to the nitrilase superfamily, branch 1.1 auxin-producing nitrilase, overview | Arabidopsis thaliana |
| 3.5.5.1 | NIT1 | - |
Arabidopsis thaliana |
| 3.5.5.7 | cyanoalanine hydratase/nitrilase | - |
Arabidopsis thaliana |
| 3.5.5.7 | More | the enzyme belongs to branch 1.4 of the superfamily of nitrilases, overview | Arabidopsis thaliana |
| 3.5.5.7 | More | the enzyme belongs to the superfamily of nitrilases, branch 1.2 aliphatic nitrilases, overview | Rhodococcus rhodochrous |
| 3.5.5.7 | Nit4 | - |
Arabidopsis thaliana |
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Release 2023.1 (January 2023)
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