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Literature summary extracted from

  • Iwaki-Egawa, S.; Namiki, C.; Watanabe, Y.
    Adenosine deaminase 2 from chicken liver: purification, characterization, and N-terminal amino acid sequence (2004), Comp. Biochem. Physiol. B, 137, 247-254.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.4 2'-deoxycoformycin 0.15 nM, 50% inhibition Gallus gallus
3.5.4.4 additional information no inhibition by erythro-9-(2-hydroxy-3-nonyl)-adenine hydrochloride Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.4 0.144
-
 adenosine
-
 Gallus gallus
3.5.4.4 0.333
-
 2'-deoxyadenosine
-
 Gallus gallus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.4 61000
-
 2 * 61000, SDS-PAGE Gallus gallus
3.5.4.4 110000
-
 gel filtration Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.4 additional information Gallus gallus the enzyme is involved in purine metabolism and plays an important role in the mechanism of the immune system ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.4 Gallus gallus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.5.4.4 glycoprotein following treatment with N-glycosidase, the molecular weight changes from 61000 Da to 55000 Da Gallus gallus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.4
-
 Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.4 liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.4 2'-deoxyadenosine + H2O 118.9% of the activity with adenosine Gallus gallus 2'-deoxyinosine + NH3
-
 ?
3.5.4.4 5'-AMP + H2O 1.4% of the activity with adenosine Gallus gallus 5'-IMP + NH3
-
 ?
3.5.4.4 adenosine + H2O
-
 Gallus gallus inosine + NH3
-
 ?
3.5.4.4 additional information the enzyme is involved in purine metabolism and plays an important role in the mechanism of the immune system Gallus gallus ?
-
 ?
3.5.4.4 additional information no activity with 3'-deoxyadenosine, 2',3'-deoxyadenosine and 2'-O-methyladenosine Gallus gallus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.4.4 dimer 2 * 61000, SDS-PAGE Gallus gallus

Synonyms

EC Number Synonyms Comment Organism
3.5.4.4 ADA2
-
 Gallus gallus
3.5.4.4 adenosine deaminase 2
-
 Gallus gallus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.4 6.5
-
-
 Gallus gallus