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Literature summary extracted from

  • Cabeza, M.; Flores, E.; Heuze, I.; Sanchez, M.; Bratoeff, E.; Ramirez, E.; Francolugo, V.A.
    Novel 17 substituted pregnadiene derivatives as 5alpha-reductase inhibitors and their binding affinity for the androgen receptor (2004), Chem. Pharm. Bull., 52, 535-539.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 6-methylene-17alpha-(2-cyclohexylacetoxy)-pregn-4-ene-3,20-dione
-
 Mesocricetus auratus
1.3.1.22 6-methylene-17alpha-(3-cyclohexylpropionyloxy)-pregn-4-ene-3,20-dione
-
 Mesocricetus auratus
1.3.1.22 6-methylene-17alpha-(3-cyclopentylpropionyloxy)-pregn-4-ene-3,20-dione
-
 Mesocricetus auratus
1.3.1.22 6-methylene-17alpha-(4-cyclohexylbutyryloxy)-pregn-4-ene-3,20-dione
-
 Mesocricetus auratus
1.3.1.22 beta-sitosterol
-
 Mesocricetus auratus
1.3.1.22 additional information synthesis and inhibitory potency of compounds, IC50 values, and affinity for the androgen receptor in prostate, overview Mesocricetus auratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.22 cytosol
-
 Mesocricetus auratus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.22 testosterone + NADPH + H+ Mesocricetus auratus
-
 5alpha-dihydrotestosterone + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Mesocricetus auratus
-
 golden hamster, male
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 prostate from gonadectomized male hamster Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 testosterone + NADPH + H+
-
 Mesocricetus auratus 5alpha-dihydrotestosterone + NADP+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.22 37
-
 assay at Mesocricetus auratus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.22 6.5
-
 assay at Mesocricetus auratus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Mesocricetus auratus