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Literature summary extracted from

  • Jiang, X.R.; Dryhurst, G.
    Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione (2002), Chem. Res. Toxicol., 15, 1242-1247.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.104 ADP stimulates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.104 tryptamine-4,5-dione inhibition is blocked by reduced glutathione or cysteine at large molar excess, ascorbate protects partially Rattus norvegicus
1.2.1.105 tryptamine-4,5-dione rapid inhibition, 87.7% reduced activity at 0.1 mM, inhibition is blocked by reduced glutathione or cysteine at large molar excess, ascorbate protects partially, inhibition is not affected by catalase and superoxide dismutase Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.104 microsome
-
 Rattus norvegicus
-
-
1.2.1.104 mitochondrion
-
 Rattus norvegicus 5739
-
1.2.1.105 membrane
-
 Rattus norvegicus 16020
-
1.2.1.105 microsome
-
 Rattus norvegicus
-
-
1.2.1.105 mitochondrion
-
 Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.104 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.104 additional information Rattus norvegicus pyruvate-supported mitochondrial respiration state 3 ?
-
 ?
1.2.1.105 additional information Rattus norvegicus 2-oxoglutarate-supported mitochondrial respiration state 3 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.104 Rattus norvegicus
-
 enzyme is in complex with alpha-ketoglutarate dehydrogenase
-
1.2.1.105 Rattus norvegicus
-
 enzyme is in complex with pyruvate dehydrogenase
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.104 brain
-
 Rattus norvegicus
-
1.2.1.105 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.104 additional information pyruvate-supported mitochondrial respiration state 3 Rattus norvegicus ?
-
 ?
1.2.1.104 pyruvate + CoA + NAD+
-
 Rattus norvegicus acetyl-CoA + CO2 + NADH
-
 ir
1.2.1.105 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
 Rattus norvegicus [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
 ir
1.2.1.105 additional information 2-oxoglutarate-supported mitochondrial respiration state 3 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.104 PDHC enzyme in complex with alpha-ketoglutarate dehydrogenase Rattus norvegicus
1.2.1.104 pyruvate dehydrogenase complex enzyme in complex with alpha-ketoglutarate dehydrogenase Rattus norvegicus
1.2.1.105 alpha-ketoglutarate dehydrogenase complex enzyme in complex with pyruvate dehydrogenase Rattus norvegicus
1.2.1.105 PDHC enzyme in complex with alpha-ketoglutarate dehydrogenase Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.104 30
-
 assay at Rattus norvegicus
1.2.1.105 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.104 7.4
-
 assay at Rattus norvegicus
1.2.1.105 7.4
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.104 NAD+
-
 Rattus norvegicus
1.2.1.104 thiamine diphosphate
-
 Rattus norvegicus
1.2.1.105 NAD+
-
 Rattus norvegicus