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Literature summary extracted from

  • Maser, E.; Friebertshauser, J.; Volker, B.
    Purification, characterization and NNK carbonyl reductase activities of 11beta-hydroxysteroid dehydrogenase type 1 from human liver: enzyme cooperativity and significance in the detoxification of a tobacco-derived carcinogen (2003), Chem. Biol. Interact., 143-144, 435-448.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 glycyrrhetinic acid
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.146 0.041
-
 cortisol
-
 Homo sapiens
1.1.1.146 0.043
-
 corticosterone
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.146 endoplasmic reticulum
-
 Homo sapiens 5783
-
1.1.1.146 membrane membrane bound Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.146 34000
-
 2 * 34000, SDS-PAGE Homo sapiens
1.1.1.146 67400
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+ Homo sapiens bidirectional reaction in vitro, it is suggested that in vivo 11beta-HSD 1 functions primarly as reductase, reactivating inert 11-oxo glucocorticoids to the corresponding receptor-active 11beta-hydroxy forms cortisol + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.146 Octyl-Sepharose, Mono Q-Sepharose, Red-Sepharose Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 11-dehydrocorticosterone + NADPH + H+
-
 Homo sapiens corticosterone + NADP+
-
 r
1.1.1.146 4-methylnitrosamine-1-(3-pyridiyl)-1-butanone + NADPH
-
 Homo sapiens 4-methylnitrosamine-1-(3-pyridiyl)-1-butanol + NADP+
-
 ?
1.1.1.146 corticosterone + NADPH + H+
-
 Homo sapiens corticosterol + NADP+
-
 r
1.1.1.146 cortisone + NADPH + H+ bidirectional reaction in vitro, it is suggested that in vivo 11beta-HSD 1 functions primarly as reductase, reactivating inert 11-oxo glucocorticoids to the corresponding receptor-active 11beta-hydroxy forms Homo sapiens cortisol + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.146 dimer 2 * 34000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.146 0.000005
-
 glycyrrhetinic acid vs. cortisol Homo sapiens
1.1.1.146 0.00001
-
 glycyrrhetinic acid vs. 4-methylnitrosamine-1-(3-pyridiyl)-1-butanone Homo sapiens
1.1.1.146 0.000014
-
 glycyrrhetinic acid vs. cortisone Homo sapiens