Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Vander Jagt, D.L.; Hunsaker, L.A.
    Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase (2003), Chem. Biol. Interact., 143-144, 341-351.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.49 Amines several amines stimulate activity Homo sapiens
1.2.1.49 DL-2-amino-1-propanol required, best activator of the reaction Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.49 40000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.49 methylglyoxal + NADP+ + H2O Homo sapiens contributes to the detoxification of methylglyoxal pyruvate + NADPH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.49 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.49
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.49 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.49 methylglyoxal + NADP+ + H2O
-
 Homo sapiens pyruvate + NADPH
-
 ?
1.2.1.49 methylglyoxal + NADP+ + H2O contributes to the detoxification of methylglyoxal Homo sapiens pyruvate + NADPH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.49 monomer
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.49 9.5
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.49 8.5 10 very low activity at physiological pH Homo sapiens