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Literature summary extracted from

  • Srivastava, S.K.; Ramana, K.V.; Chandra, D.; Srivastava, S.; Bhatnagar, A.
    Regulation of aldose reductase and the polyol pathway activity by nitric oxide (2003), Chem. Biol. Interact., 143-144, 333-340.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.21 N-(beta-glucopyranosyl)-N2-acetyl-S-nitroso-N-acetylpenicillamine 2 mM, up to 7fold increase in activity, possibly due to nitrosation of Cys298 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 3-morpholino syndnonimine 1 mM, 76% inhibition, reversed by incubation with fresh media Rattus norvegicus
1.1.1.21 S-nitroso-N-acetylpenicillamine 1 mM, 86% inhibition, reversed by incubation with fresh media Rattus norvegicus
1.1.1.21 S-nitrosoglutathione 0.05 mM, up to 40% inhibition, possibly due to selctive formation of a single mixed disulfide between glutathione and Cys298 Homo sapiens
1.1.1.21 S-nitrosoglutathione 1 mM, 70% inhibition, reversed by incubation with fresh media Rattus norvegicus
1.1.1.21 S-nitrosoglutathione monoethylester 1 mM, 73% inhibition, reversed by incubation with fresh media Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
 recombinant enzyme
-
1.1.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 erythrocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 glucose + NADPH
-
 Homo sapiens sorbitol + NADP+
-
 ?
1.1.1.21 glucose + NADPH
-
 Rattus norvegicus sorbitol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 AKR1B
-
 Homo sapiens
1.1.1.21 AKR1B
-
 Rattus norvegicus