EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.1.4 | expression of the wild type and several mutants in Escherichia coli | Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.5.1.4 | C249A | inhibition of the mutant by ibuprofen is similar than that of wild type | Rattus norvegicus |
3.5.1.4 | S152A | inhibition of the mutant by ibuprofen is similar than that of wild type | Rattus norvegicus |
3.5.1.4 | S218A | inactive mutant | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.4 | arachidonoyl serotonin | more potent inhibitor at pH 8.4 than at pH 5.3 | Rattus norvegicus | |
3.5.1.4 | Ibuprofen | both enantiomers, more potent inhibitors at pH 5.3 than at pH 8.4 | Rattus norvegicus | |
3.5.1.4 | oleoyltrifluoromethylketone | more potent inhibitor at pH 5.3 than at pH 8.4 | Rattus norvegicus | |
3.5.1.4 | phenylmethyl sulfonyl fluoride | more potent inhibitor at pH 8.4 than at pH 5.3 | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.1.4 | 0.0033 | - |
arachidonoyl-ethanolamine | pH 7.3, 37°C | Rattus norvegicus | |
3.5.1.4 | 0.0036 | - |
arachidonoyl-ethanolamine | pH 6.3, 37°C | Rattus norvegicus | |
3.5.1.4 | 0.0041 | - |
arachidonoyl-ethanolamine | pH 8.2, 37°C | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.4 | Rattus norvegicus | - |
adults | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.1.4 | brain | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.4 | arachidonoyl-ethanolamine + H2O | hydrolysis of anandamide | Rattus norvegicus | arachidonic acid + ethanolamine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.1.4 | FAAH | - |
Rattus norvegicus |
3.5.1.4 | fatty acid amide hydrolase | - |
Rattus norvegicus |