Literature summary extracted from

Carbone, V.; Darmanin, C.; Ishikura, S.; Hara, A.; El-Kabbani, O.
Structure-based design of inhibitors of human L-xylulose reductase modelled into the active site of the enzyme (2003), Bioorg. Med. Chem. Lett., 13, 1469-1474.

Application

EC Number	Application	Comment	Organism
1.1.1.10	pharmacology	enzyme is a target for design and development of potent and specific structure-based inhibitors binding in the active site	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.10	additional information	modelling of structure-based inhibitor binding into the active site	Homo sapiens
1.1.1.10	n-butyric acid	binds to the active site of the enzyme, complex structure determination and analysis	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.1.1.10	brush border	-	Homo sapiens	5903	-
1.1.1.10	membrane	-	Homo sapiens	16020	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.10	L-xylulose + NADPH + H+	Homo sapiens	part of the glucuronic acid pathway, enzyme may be involved in water reabsorption and cellular osmoregulation	L-xylitol + NADP+	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.10	Homo sapiens	-	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
1.1.1.10	xylitol + NADP+ = L-xylulose + NADPH + H+	active site structure	Homo sapiens	a

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.10	kidney	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.10	L-xylulose + NADPH + H+	-	Homo sapiens	L-xylitol + NADP+	-	r
1.1.1.10	L-xylulose + NADPH + H+	part of the glucuronic acid pathway, enzyme may be involved in water reabsorption and cellular osmoregulation	Homo sapiens	L-xylitol + NADP+	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.10	XR	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.10	NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)