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Literature summary extracted from

  • Lash, T.D.; Kaprak, T.A.; Shen, L.; Jones, M.A.
    Metabolism of analogues of coproporphyrinogen-III with modified side chains: implications for binding at the active site of coproporphyrinogen oxidase (2002), Bioorg. Med. Chem. Lett., 12, 451-456.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 Gallus gallus pathway overview protoporphyrinogen-IX + CO2 + H2O
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?
1.3.3.3 coproporphyrinogen-III + O2 Euglena gracilis pathway overview protoporphyrinogen-IX + CO2 + H2O
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?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Euglena gracilis
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-
-
1.3.3.3 Gallus gallus
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-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.3.3 coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O substrate binding at the active site, structure and mechanism, catalytic mechanism Gallus gallus
1.3.3.3 coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O substrate binding at the active site, structure and mechanism, catalytic mechanism Euglena gracilis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.3 erythrocyte
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Gallus gallus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 pathway overview Gallus gallus protoporphyrinogen-IX + CO2 + H2O
-
?
1.3.3.3 coproporphyrinogen-III + O2 pathway overview Euglena gracilis protoporphyrinogen-IX + CO2 + H2O
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?
1.3.3.3 coproporphyrinogen-III + O2 coproporphyrinogen analogues with modified propionate side chains bearing methyl substitutents are moderate substrates for the enzyme giving divinylic products, overview Euglena gracilis protoporphyrinogen-IX + CO2 + H2O
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?
1.3.3.3 coproporphyrinogen-III + O2 sequential oxidative decarboxylations at the A and B rings, synthetic coproporphyrinogen analogues with modified methylated propionate side chains are moderate substrates for the enzyme giving divinylic products, overview Gallus gallus protoporphyrinogen-IX + CO2 + H2O
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?
1.3.3.3 coproporphyrinogen-IV + O2 synthetic coproporphyrinogen analogues with modified propionate side chains Gallus gallus ?
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?
1.3.3.3 coproporphyrinogen-IV + O2 synthetic coproporphyrinogen analogues with modified propionate side chains Euglena gracilis ?
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?
1.3.3.3 mesoproporphyrinogen-VI + O2 synthetic coproporphyrinogen analogues with modified propionate side chains Gallus gallus ?
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?
1.3.3.3 mesoproporphyrinogen-VI + O2 synthetic coproporphyrinogen analogues with modified propionate side chains Euglena gracilis ?
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?
1.3.3.3 additional information substrate specificity with diverse coproporphyrinogen-derived compounds, overview, alterations of substituents involved in secondary binding interactions have a comparable affect to modifying the side chain that undergoes degradation at the catalytic site, no hyroxylated products Gallus gallus ?
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?
1.3.3.3 additional information substrate specificity with diverse coproporphyrinogen-derived compounds, overview, alterations of substituents involved in secondary binding interactions have a comparable affect to modifying the side chain that undergoes degradation at the catalytic site, porphyrinogen carboxylic acids are unstable, no hyroxylated products Euglena gracilis ?
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?