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Literature summary extracted from

  • Da Settimo, F.; Primofiore, G.; La Motta, C.; Salerno, S.; Novellino, E.; Greco, G.; Lavecchia, A.; Laneri, S.; Boldrini, E.
    Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors (2005), Bioorg. Med. Chem., 13, 491-499.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 2,3-dihydrospiro[4H-thiopyrano[2,3-b]pyridin-4,4'imidazolidine]-2',5'-dione 50% inhibition at 0.0034 mM Rattus norvegicus
1.1.1.21 2,3-dihydrospiro[4H-thiopyrano[2,3-b]pyridin-4,4'imidazolidine]-2',5'-dione, sulfone derivative 50% inhibition at 0.0014 mM Rattus norvegicus
1.1.1.21 7-methyl-2,3-dihydrospiro[4H-thiopyrano[2,3-b]pyridin-4,4'imidazolidine]-2',5'-dione 50% inhibition at 0.0011 mM Rattus norvegicus
1.1.1.21 additional information model of inhibitor binding interactions Rattus norvegicus
1.1.1.21 N-acetyl-2,3-dihydrospiro[4H-thiopyrano[2,3-b]pyridin-4,4'imidazolidine]-2',5'-dione 50% inhibition at 0.050 mM Rattus norvegicus
1.1.1.21 quercetin
-
 Rattus norvegicus
1.1.1.21 sorbinil 50% inhibition at 29 nM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
 Rattus norvegicus
-