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Literature summary extracted from

  • Haslett, M.R.; Pink, D.; Walters, B.; Brosnan, M.E.
    Assay and subcellular localization of pyrroline-5-carboxylate dehydrogenase in rat liver (2004), Biochim. Biophys. Acta, 1675, 81-86.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.88 mitochondrion exclusively Rattus norvegicus 5739
-
1.5.1.2 mitochondrial matrix
-
 Rattus norvegicus 5759
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.88 1-pyrroline-5-carboxylate + NAD+ + H2O Rattus norvegicus
-
 L-glutamate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.88 Rattus norvegicus
-
 male sprague-dawley rats
-
1.5.1.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.88 subcellular fractionation, isolation of mitochondria Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.88 liver
-
 Rattus norvegicus
-
1.5.1.2 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.88 0.19
-
 mitochondrial fraction, with cofactor NADP+ Rattus norvegicus
1.2.1.88 0.3
-
 mitochondrial fraction, with cofactor NAD+ Rattus norvegicus
1.5.1.2 additional information
-
 assay method Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.88 1-pyrroline-5-carboxylate + NAD(P)+ + H2O
-
 Rattus norvegicus L-glutamate + NAD(P)H
-
 ?
1.2.1.88 1-pyrroline-5-carboxylate + NAD+ + H2O
-
 Rattus norvegicus L-glutamate + NADH
-
 ?
1.5.1.2 L-Pro + NAD+
-
 Rattus norvegicus 1-pyrroline-5-carboxylate + NADH
-
 ?
1.5.1.2 L-Pro + NADP+
-
 Rattus norvegicus 1-pyrroline-5-carboxylate + NADPH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.88 DELTA1-pyrroline-5-carboxylate dehydrogenase
-
 Rattus norvegicus
1.2.1.88 P5CDH
-
 Rattus norvegicus
1.5.1.2 P5CDH
-
 Rattus norvegicus
1.5.1.2 proline oxidase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.88 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.88 7.8
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.88 NAD+ preferred cofactor Rattus norvegicus
1.2.1.88 NADP+
-
 Rattus norvegicus
1.5.1.2 NAD+
-
 Rattus norvegicus
1.5.1.2 NADP+
-
 Rattus norvegicus