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Literature summary extracted from

  • Demenis, M.A.; Furriel, R.P.M.; Leone, F.A.
    Characterization of an ectonucleoside triphosphate diphosphohydrolase 1 activity in alkaline phosphatase-depleted rat osseous plate membranes: possible functional involvement in the calcification process (2003), Biochim. Biophys. Acta, 1646, 216-225.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.5 additional information not inhibitory: oligomycin, ouabain, bafilomycin A, theophylline, thapsigarin, ethacrynic acid, P1,P5-(adenosine-5’)pentyphosphate, omeprazole Rattus norvegicus
3.6.1.5 Sodium azide
-
Rattus norvegicus
3.6.1.5 suramin
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.5 0.083
-
ATP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
3.6.1.5 0.085
-
ATP pH 7.5, 37°C, presence of Ca2+ Rattus norvegicus
3.6.1.5 0.148
-
CTP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
3.6.1.5 0.15
-
ADP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
3.6.1.5 0.164
-
GTP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
3.6.1.5 0.196
-
ADP pH 7.5, 37°C, presence of Ca2+ Rattus norvegicus
3.6.1.5 0.207
-
UTP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
3.6.1.5 0.259
-
ITP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
3.6.1.5 0.357
-
GDP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
3.6.1.5 0.555
-
UDP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
3.6.1.5 0.622
-
IDP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
3.6.1.5 0.777
-
CDP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.5 membrane
-
Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.5 Ca2+ or Mg2+, required, Km-value 0.377 mM Rattus norvegicus
3.6.1.5 Mg2+ or Ca2+, required, Km-value 0.595 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.5 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.5 osseous plate alkaline phosphatase depleted Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.5 ADP + H2O
-
Rattus norvegicus AMP + phosphate
-
?
3.6.1.5 ATP + 2 H2O
-
Rattus norvegicus AMP + 2 phosphate
-
?
3.6.1.5 CDP + H2O
-
Rattus norvegicus CMP + phosphate
-
?
3.6.1.5 CTP + 2 H2O
-
Rattus norvegicus CMP + 2 phosphate
-
?
3.6.1.5 GDP + H2O
-
Rattus norvegicus GMP + phosphate
-
?
3.6.1.5 GTP + 2 H2O
-
Rattus norvegicus GMP + 2 phosphate
-
?
3.6.1.5 IDP + H2O
-
Rattus norvegicus IMP + phosphate
-
?
3.6.1.5 ITP + 2 H2O
-
Rattus norvegicus IMP + 2 phosphate
-
?
3.6.1.5 UDP + H2O
-
Rattus norvegicus UMP + phosphate
-
?
3.6.1.5 UTP + 2 H2O
-
Rattus norvegicus UMP + 2 phosphate
-
?